Literature DB >> 18475650

Serum levels of soluble IL-2R, CD4 and CD8 in bronChial asthma.

G D Lorenzo1, P Mansueto, M Melluso, G Morici, F Norrito, D Cigna, G Candore, C Caruso.   

Abstract

The aim of the present study was to compare serum levels of soluble forms of interleukin-2 receptor, CD4 and CD8, released by lymphocytes during activation of the immune system, in patients with allergic bronchial asthma, with those in healthy subjects. Significantly higher levels of soluble IL-2R and soluble CD4 were found in patients with asthma compared with the control group. In contrast, lower levels of soluble CD8 values were found in patients with asthma compared to the control group. Significant correlations were found for both sIL-2R and sCD4 and these two molecules, with lung function measured as bronchial responsiveness to inhaled methacholine. These results strengthen previous suggestions that in allergic bronchial asthma, activation of T cells plays a significant role in the disease pathogenesis.

Entities:  

Year:  1995        PMID： 18475650      PMCID： PMC2365642          DOI： 10.1155/S0962935195000433

Source DB:  PubMed          Journal:  Mediators Inflamm        ISSN： 0962-9351            Impact factor:   4.711


  10 in total

1.  Interleukin 2 and soluble interleukin 2-receptor secretion defect in vitro in newly diagnosed type I diabetic patients.

Authors:  C Giordano; F Pantò; C Caruso; M A Modica; A M Zambito; N Sapienza; M P Amato; A Galluzzo
Journal:  Diabetes       Date:  1989-03       Impact factor: 9.461

2.  In vitro cytokine production by HLA-B8,DR3 positive subjects.

Authors:  G Candore; D Cigna; F Gervasi; A T Colucci; M A Modica; C Caruso
Journal:  Autoimmunity       Date:  1994       Impact factor: 2.815

3.  Serum concentration of soluble interleukin 2 receptors in asthma. Correlation with disease activity.

Authors:  C K Lai; C H Chan; J C Leung; K N Lai
Journal:  Chest       Date:  1993-03       Impact factor: 9.410

4.  Soluble IL-2-receptor and CD8 in the serum and the periparasitic granuloma of patients with alveolar echinococcosis.

Authors:  S Bresson-Hadni; B Monnot-Jacquard; E Racadot; D Lenys; J P Miguet; D A Vuitton
Journal:  Eur Cytokine Netw       Date:  1991 Nov-Dec       Impact factor: 2.737

5.  Predominant TH2-like bronchoalveolar T-lymphocyte population in atopic asthma.

Authors:  D S Robinson; Q Hamid; S Ying; A Tsicopoulos; J Barkans; A M Bentley; C Corrigan; S R Durham; A B Kay
Journal:  N Engl J Med       Date:  1992-01-30       Impact factor: 91.245

6.  Soluble CD4 in patients with rheumatoid arthritis and osteoarthritis.

Authors:  J A Symons; J F McCulloch; N C Wood; G W Duff
Journal:  Clin Immunol Immunopathol       Date:  1991-07

7.  Atopic dermatitis: correlation of peripheral blood T cell activation, eosinophilia and serum factors with clinical severity.

Authors:  C Walker; M K Kägi; P Ingold; P Braun; K Blaser; C A Bruijnzeel-Koomen; B Wüthrich
Journal:  Clin Exp Allergy       Date:  1993-02       Impact factor: 5.018

8.  CD4 T-lymphocyte activation in acute severe asthma. Relationship to disease severity and atopic status.

Authors:  C J Corrigan; A B Kay
Journal:  Am Rev Respir Dis       Date:  1990-04

9.  Biological significance of soluble IL-2 receptor.

Authors:  C Caruso; G Candore; D Cigna; A T Colucci; M A Modica
Journal:  Mediators Inflamm       Date:  1993       Impact factor: 4.711

10.  Serum Levels of Soluble IL-2R, CD4 and CD8 in Chronic Active HCV Positive Hepatitis.

Authors:  C Caruso; G Candore; D Cigna; S Tripi; G Di Gaetano; G Migneco; G Montalto; I Ruggieri; A Notarbartolo
Journal:  Mediators Inflamm       Date:  1994       Impact factor: 4.711
  10 in total
  1 in total

1.  Serum levels of total IgE and soluble CD23 in bronchial asthma.

Authors:  G D Lorenzo; P Mansueto; M Melluso; G Morici; D Cigna; G Candore; C Caruso
Journal:  Mediators Inflamm       Date:  1996       Impact factor: 4.711
  1 in total

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