| Literature DB >> 18474224 |
Norihiko Ohbayashi1, Shiho Kawakami, Ryuta Muromoto, Sumihito Togi, Osamu Ikeda, Shinya Kamitani, Yuichi Sekine, Tsutomu Honjoh, Tadashi Matsuda.
Abstract
Post-translational modification by small ubiquitin-like modifier (SUMO) plays an important role in the regulation of different signaling pathways and is involved in the formation of promyelocytic leukemia (PML) protein nuclear bodies following sumoylation of PML. In the present study, we found that IL-6 induces desumoylation of PML and dissociation between PML and SUMO1 in hepatoma cells. We also found that IL-6 induces mRNA expression of SENP1, a member of the SUMO-specific protease family. Furthermore, wild-type SENP1 but not an inactive SENP1 mutant restored the PML-mediated suppression of STAT3 activation. These results indicate that the IL-6 family of cytokines modulates STAT3 activation by desumoylation and inactivation PML through SENP1 induction.Entities:
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Year: 2008 PMID： 18474224 DOI： 10.1016/j.bbrc.2008.04.179
Source DB: PubMed Journal: Biochem Biophys Res Commun ISSN： 0006-291X Impact factor: 3.575