Literature DB >> 18474209

NOS1AP in schizophrenia.

Linda M Brzustowicz1.   

Abstract

NOS1AP is an attractive candidate gene for schizophrenia susceptibility. Linkage and association studies from multiple samples drawn from different populations indicate that a schizophrenia susceptibility gene is located in the region of chromosome 1 containing NOS1AP. Increased NOS1AP expression is observed in postmortem samples from individuals with schizophrenia. NOS1AP binds to neuronal nitric oxide synthase and synapsin, other candidate genes for schizophrenia, and may disrupt signal transduction through the N-methyl d-aspartate receptor complex, leading to hypofunctioning of that system. In this review, I present the evidence supporting NOS1AP as a schizophrenia susceptibility gene, with a focus on explaining the strengths and weaknesses of the evidence obtained from each type of study that has been conducted.

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Year:  2008        PMID： 18474209      PMCID： PMC3987957          DOI： 10.1007/s11920-008-0027-0

Source DB:  PubMed          Journal:  Curr Psychiatry Rep        ISSN： 1523-3812            Impact factor:   5.285


  40 in total

1.  The International HapMap Project.

Authors: 
Journal:  Nature       Date:  2003-12-18       Impact factor: 49.962

2.  Pathology of layer V pyramidal neurons in the prefrontal cortex of patients with schizophrenia.

Authors:  James E Black; Ian M Kodish; Aaron W Grossman; Anna Y Klintsova; Diana Orlovskaya; Victor Vostrikov; Natalya Uranova; William T Greenough
Journal:  Am J Psychiatry       Date:  2004-04       Impact factor: 18.112

3.  Size matters: the unexpected challenge of detecting linkage in large cohorts.

Authors:  Linda M Brzustowicz
Journal:  Am J Psychiatry       Date:  2007-02       Impact factor: 18.112

4.  Replicating genotype-phenotype associations.

Authors:  Stephen J Chanock; Teri Manolio; Michael Boehnke; Eric Boerwinkle; David J Hunter; Gilles Thomas; Joel N Hirschhorn; Goncalo Abecasis; David Altshuler; Joan E Bailey-Wilson; Lisa D Brooks; Lon R Cardon; Mark Daly; Peter Donnelly; Joseph F Fraumeni; Nelson B Freimer; Daniela S Gerhard; Chris Gunter; Alan E Guttmacher; Mark S Guyer; Emily L Harris; Josephine Hoh; Robert Hoover; C Augustine Kong; Kathleen R Merikangas; Cynthia C Morton; Lyle J Palmer; Elizabeth G Phimister; John P Rice; Jerry Roberts; Charles Rotimi; Margaret A Tucker; Kyle J Vogan; Sholom Wacholder; Ellen M Wijsman; Deborah M Winn; Francis S Collins
Journal:  Nature       Date:  2007-06-07       Impact factor: 49.962

5.  Interaction of nitric oxide synthase with the postsynaptic density protein PSD-95 and alpha1-syntrophin mediated by PDZ domains.

Authors:  J E Brenman; D S Chao; S H Gee; A W McGee; S E Craven; D R Santillano; Z Wu; F Huang; H Xia; M F Peters; S C Froehner; D S Bredt
Journal:  Cell       Date:  1996-03-08       Impact factor: 41.582

Review 6.  The strength of the genetic effect. Is there room for an environmental influence in the aetiology of schizophrenia?

Authors:  P McGuffin; P Asherson; M Owen; A Farmer
Journal:  Br J Psychiatry       Date:  1994-05       Impact factor: 9.319

7.  Mood-incongruent psychotic features in bipolar disorder: familial aggregation and suggestive linkage to 2p11-q14 and 13q21-33.

Authors:  Fernando S Goes; Peter P Zandi; Kuangyi Miao; Francis J McMahon; Jo Steele; Virginia L Willour; Dean F Mackinnon; Francis M Mondimore; Barbara Schweizer; John I Nurnberger; John P Rice; William Scheftner; William Coryell; Wade H Berrettini; John R Kelsoe; William Byerley; Dennis L Murphy; Elliot S Gershon; J Raymond Depaulo; Melvin G McInnis; James B Potash
Journal:  Am J Psychiatry       Date:  2007-02       Impact factor: 18.112

8.  Finishing the euchromatic sequence of the human genome.

Authors: 
Journal:  Nature       Date:  2004-10-21       Impact factor: 49.962

9.  A second generation human haplotype map of over 3.1 million SNPs.

Authors:  Kelly A Frazer; Dennis G Ballinger; David R Cox; David A Hinds; Laura L Stuve; Richard A Gibbs; John W Belmont; Andrew Boudreau; Paul Hardenbol; Suzanne M Leal; Shiran Pasternak; David A Wheeler; Thomas D Willis; Fuli Yu; Huanming Yang; Changqing Zeng; Yang Gao; Haoran Hu; Weitao Hu; Chaohua Li; Wei Lin; Siqi Liu; Hao Pan; Xiaoli Tang; Jian Wang; Wei Wang; Jun Yu; Bo Zhang; Qingrun Zhang; Hongbin Zhao; Hui Zhao; Jun Zhou; Stacey B Gabriel; Rachel Barry; Brendan Blumenstiel; Amy Camargo; Matthew Defelice; Maura Faggart; Mary Goyette; Supriya Gupta; Jamie Moore; Huy Nguyen; Robert C Onofrio; Melissa Parkin; Jessica Roy; Erich Stahl; Ellen Winchester; Liuda Ziaugra; David Altshuler; Yan Shen; Zhijian Yao; Wei Huang; Xun Chu; Yungang He; Li Jin; Yangfan Liu; Yayun Shen; Weiwei Sun; Haifeng Wang; Yi Wang; Ying Wang; Xiaoyan Xiong; Liang Xu; Mary M Y Waye; Stephen K W Tsui; Hong Xue; J Tze-Fei Wong; Luana M Galver; Jian-Bing Fan; Kevin Gunderson; Sarah S Murray; Arnold R Oliphant; Mark S Chee; Alexandre Montpetit; Fanny Chagnon; Vincent Ferretti; Martin Leboeuf; Jean-François Olivier; Michael S Phillips; Stéphanie Roumy; Clémentine Sallée; Andrei Verner; Thomas J Hudson; Pui-Yan Kwok; Dongmei Cai; Daniel C Koboldt; Raymond D Miller; Ludmila Pawlikowska; Patricia Taillon-Miller; Ming Xiao; Lap-Chee Tsui; William Mak; You Qiang Song; Paul K H Tam; Yusuke Nakamura; Takahisa Kawaguchi; Takuya Kitamoto; Takashi Morizono; Atsushi Nagashima; Yozo Ohnishi; Akihiro Sekine; Toshihiro Tanaka; Tatsuhiko Tsunoda; Panos Deloukas; Christine P Bird; Marcos Delgado; Emmanouil T Dermitzakis; Rhian Gwilliam; Sarah Hunt; Jonathan Morrison; Don Powell; Barbara E Stranger; Pamela Whittaker; David R Bentley; Mark J Daly; Paul I W de Bakker; Jeff Barrett; Yves R Chretien; Julian Maller; Steve McCarroll; Nick Patterson; Itsik Pe'er; Alkes Price; Shaun Purcell; Daniel J Richter; Pardis Sabeti; Richa Saxena; Stephen F Schaffner; Pak C Sham; Patrick Varilly; David Altshuler; Lincoln D Stein; Lalitha Krishnan; Albert Vernon Smith; Marcela K Tello-Ruiz; Gudmundur A Thorisson; Aravinda Chakravarti; Peter E Chen; David J Cutler; Carl S Kashuk; Shin Lin; Gonçalo R Abecasis; Weihua Guan; Yun Li; Heather M Munro; Zhaohui Steve Qin; Daryl J Thomas; Gilean McVean; Adam Auton; Leonardo Bottolo; Niall Cardin; Susana Eyheramendy; Colin Freeman; Jonathan Marchini; Simon Myers; Chris Spencer; Matthew Stephens; Peter Donnelly; Lon R Cardon; Geraldine Clarke; David M Evans; Andrew P Morris; Bruce S Weir; Tatsuhiko Tsunoda; James C Mullikin; Stephen T Sherry; Michael Feolo; Andrew Skol; Houcan Zhang; Changqing Zeng; Hui Zhao; Ichiro Matsuda; Yoshimitsu Fukushima; Darryl R Macer; Eiko Suda; Charles N Rotimi; Clement A Adebamowo; Ike Ajayi; Toyin Aniagwu; Patricia A Marshall; Chibuzor Nkwodimmah; Charmaine D M Royal; Mark F Leppert; Missy Dixon; Andy Peiffer; Renzong Qiu; Alastair Kent; Kazuto Kato; Norio Niikawa; Isaac F Adewole; Bartha M Knoppers; Morris W Foster; Ellen Wright Clayton; Jessica Watkin; Richard A Gibbs; John W Belmont; Donna Muzny; Lynne Nazareth; Erica Sodergren; George M Weinstock; David A Wheeler; Imtaz Yakub; Stacey B Gabriel; Robert C Onofrio; Daniel J Richter; Liuda Ziaugra; Bruce W Birren; Mark J Daly; David Altshuler; Richard K Wilson; Lucinda L Fulton; Jane Rogers; John Burton; Nigel P Carter; Christopher M Clee; Mark Griffiths; Matthew C Jones; Kirsten McLay; Robert W Plumb; Mark T Ross; Sarah K Sims; David L Willey; Zhu Chen; Hua Han; Le Kang; Martin Godbout; John C Wallenburg; Paul L'Archevêque; Guy Bellemare; Koji Saeki; Hongguang Wang; Daochang An; Hongbo Fu; Qing Li; Zhen Wang; Renwu Wang; Arthur L Holden; Lisa D Brooks; Jean E McEwen; Mark S Guyer; Vivian Ota Wang; Jane L Peterson; Michael Shi; Jack Spiegel; Lawrence M Sung; Lynn F Zacharia; Francis S Collins; Karen Kennedy; Ruth Jamieson; John Stewart
Journal:  Nature       Date:  2007-10-18       Impact factor: 49.962

10.  Linkage disequilibrium mapping of schizophrenia susceptibility to the CAPON region of chromosome 1q22.

Authors:  Linda M Brzustowicz; Jaime Simone; Paria Mohseni; Jared E Hayter; Kathleen A Hodgkinson; Eva W C Chow; Anne S Bassett
Journal:  Am J Hum Genet       Date:  2004-04-02       Impact factor: 11.025
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  13 in total

1.  Genome-wide strategies for discovering genetic influences on cognition and cognitive disorders: methodological considerations.

Authors:  Steven G Potkin; Jessica A Turner; Guia Guffanti; Anita Lakatos; Federica Torri; David B Keator; Fabio Macciardi
Journal:  Cogn Neuropsychiatry       Date:  2009       Impact factor: 1.871

2.  CAPON-nNOS coupling can serve as a target for developing new anxiolytics.

Authors:  Li-Juan Zhu; Ting-You Li; Chun-Xia Luo; Nan Jiang; Lei Chang; Yu-Hui Lin; Hai-Hui Zhou; Chen Chen; Yu Zhang; Wei Lu; Li-Yan Gao; Yu Ma; Qi-Gang Zhou; Qin Hu; Xiao-Ling Hu; Jing Zhang; Hai-Yin Wu; Dong-Ya Zhu
Journal:  Nat Med       Date:  2014-08-17       Impact factor: 53.440

3.  nNOS-CAPON blockers produce anxiolytic effects by promoting synaptogenesis in chronic stress-induced animal models of anxiety.

Authors:  Li-Juan Zhu; Hu-Jiang Shi; Lei Chang; Cheng Cheng Zhang; Meng Si; Na Li; Dong-Ya Zhu
Journal:  Br J Pharmacol       Date:  2020-05-28       Impact factor: 8.739

Review 4.  Identifying gene regulatory networks in schizophrenia.

Authors:  Steven G Potkin; Fabio Macciardi; Guia Guffanti; James H Fallon; Qi Wang; Jessica A Turner; Anita Lakatos; Michael F Miles; Arthur Lander; Marquis P Vawter; Xiaohui Xie
Journal:  Neuroimage       Date:  2010-06-22       Impact factor: 6.556

5.  NOS1AP protein levels are altered in BA46 and cerebellum of patients with schizophrenia.

Authors:  Norell M Hadzimichalis; Michelle L Previtera; Michael P Moreau; Bo Li; Gum Hwa Lee; Anna M Dulencin; Paul G Matteson; Steven Buyske; James H Millonig; Linda M Brzustowicz; Bonnie L Firestein
Journal:  Schizophr Res       Date:  2010-06-01       Impact factor: 4.939

6.  Nitric oxide synthase 1 adaptor protein, a protein implicated in schizophrenia, controls radial migration of cortical neurons.

Authors:  Damien Carrel; Kristina Hernandez; Munjin Kwon; Christine Mau; Meera P Trivedi; Linda M Brzustowicz; Bonnie L Firestein
Journal:  Biol Psychiatry       Date:  2014-10-30       Impact factor: 13.382

7.  NOS1AP Functionally Associates with YAP To Regulate Hippo Signaling.

Authors:  Leanne Clattenburg; Michael Wigerius; Jiansong Qi; Jan K Rainey; Jillian L Rourke; Shanmugam Muruganandan; Christopher J Sinal; James P Fawcett
Journal:  Mol Cell Biol       Date:  2015-04-27       Impact factor: 4.272

8.  Overexpression of Isoforms of Nitric Oxide Synthase 1 Adaptor Protein, Encoded by a Risk Gene for Schizophrenia, Alters Actin Dynamics and Synaptic Function.

Authors:  Kristina Hernandez; Przemyslaw Swiatkowski; Mihir V Patel; Chen Liang; Natasha R Dudzinski; Linda M Brzustowicz; Bonnie L Firestein
Journal:  Front Cell Neurosci       Date:  2016-02-02       Impact factor: 5.505

9.  Disease gene characterization through large-scale co-expression analysis.

Authors:  Allen Day; Jun Dong; Vincent A Funari; Bret Harry; Samuel P Strom; Dan H Cohn; Stanley F Nelson
Journal:  PLoS One       Date:  2009-12-31       Impact factor: 3.240

10.  Clustering of schizophrenia with other comorbidities--what can we learn?

Authors:  Braxton D Mitchell
Journal:  Schizophr Bull       Date:  2009-01-27       Impact factor: 9.306
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