Literature DB >> 18473927

Sialoglycotherapeutics in protozoal diseases.

Angana Ghoshal1, Sumi Mukhopadhyay, Chitra Mandal.   

Abstract

The manipulation of glycosylation, mainly sialylation, holds enormous potential for understanding the biological functions of glycoproteins and glycolipids to treat many diseases. The existing knowledge in the field of glycobiology is exploited by glycotherapeutics for combating protozoan diseases. This review focuses on the development of novel glycobiological therapeutic strategies in the field of protozoan infections.

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Year:  2008        PMID： 18473927     DOI： 10.2174/138955708783955980

Source DB:  PubMed          Journal:  Mini Rev Med Chem        ISSN： 1389-5575            Impact factor:   3.862


  6 in total

1.  9-O-acetylated sialoglycoproteins are important immunomodulators in Indian visceral leishmaniasis.

Authors:  Angana Ghoshal; Sumi Mukhopadhyay; Bibhuti Saha; Chitra Mandal
Journal:  Clin Vaccine Immunol       Date:  2009-04-29

2.  Sialoglycosylation of RBC in visceral leishmaniasis leads to enhanced oxidative stress, calpain-induced fragmentation of spectrin and hemolysis.

Authors:  Sajal Samanta; Angana Ghoshal; Kaushik Bhattacharya; Bibhuti Saha; Peter Walden; Chitra Mandal
Journal:  PLoS One       Date:  2012-07-31       Impact factor: 3.240

3.  Glycosylation of erythrocyte spectrin and its modification in visceral leishmaniasis.

Authors:  Sajal Samanta; Devawati Dutta; Angana Ghoshal; Sumi Mukhopadhyay; Bibhuti Saha; Shyam Sundar; Saulius Jarmalavicius; Michael Forgber; Chhabinath Mandal; Peter Walden; Chitra Mandal
Journal:  PLoS One       Date:  2011-12-02       Impact factor: 3.240

4.  Probing the acceptor substrate binding site of Trypanosoma cruzi trans-sialidase with systematically modified substrates and glycoside libraries.

Authors:  Jennifer A Harrison; K P Ravindranathan Kartha; Eric J L Fournier; Todd L Lowary; Carles Malet; Ulf J Nilsson; Ole Hindsgaul; Sergio Schenkman; James H Naismith; Robert A Field
Journal:  Org Biomol Chem       Date:  2011-01-21       Impact factor: 3.876

5.  Modulation of TLR4 Sialylation Mediated by a Sialidase Neu1 and Impairment of Its Signaling in Leishmania donovani Infected Macrophages.

Authors:  Joyshree Karmakar; Saptarshi Roy; Chitra Mandal
Journal:  Front Immunol       Date:  2019-10-09       Impact factor: 7.561

6.  Leishmania donovani Utilize Sialic Acids for Binding and Phagocytosis in the Macrophages through Selective Utilization of Siglecs and Impair the Innate Immune Arm.

Authors:  Saptarshi Roy; Chitra Mandal
Journal:  PLoS Negl Trop Dis       Date:  2016-08-05
  6 in total

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