BACKGROUND AND PURPOSE: Shigellosis is a major health problem in developing countries, causing 91 million episodes and 414,000 deaths in Asia annually. Because of increasing trends towards drug resistance, this study was undertaken to monitor local resistance patterns of Shigella isolates from 8 Asian countries. METHODS: Ninety eight Shigella isolates collected from 8 centers in 8 Asian countries from July 2001 to July 2004 were analyzed in terms of serogroup distribution and antimicrobial susceptibility. RESULTS: The most common serogroup of Shigella isolates was Shigella flexneri (49/98, 50%), followed by Shigella sonnei (44/98, 45%). The highest resistance rate was found for trimethoprim-sulfamethoxazole (81%), followed by tetracycline (74%) and ampicillin (53%). Overall, 76 Shigella isolates (78%) were multidrug-resistant strains; S. flexneri had a higher multidrug resistance rate than S. sonnei (74% vs 23%). Increasing ciprofloxacin and ceftriaxone resistance was observed; approximately 10% and 5% of isolates were resistant to ciprofloxacin and ceftriaxone, respectively. Five ceftriaxone-non-susceptible strains (from Taiwan [3], Hong Kong [1] and The Philippines [1]) and 10 ciprofloxacin-non-susceptible strains (from Hong Kong [2], The Philippines [1], Korea [2], Vietnam [4] and Sri Lanka [1]) were isolated. CONCLUSIONS: High rates of multidrug resistance and steady increases in ceftriaxone and ciprofloxacin resistance of Shigella are serious pubic health concerns in Asian countries. Continuous monitoring of resistance patterns among Shigella isolates is necessary.
BACKGROUND AND PURPOSE: Shigellosis is a major health problem in developing countries, causing 91 million episodes and 414,000 deaths in Asia annually. Because of increasing trends towards drug resistance, this study was undertaken to monitor local resistance patterns of Shigella isolates from 8 Asian countries. METHODS: Ninety eight Shigella isolates collected from 8 centers in 8 Asian countries from July 2001 to July 2004 were analyzed in terms of serogroup distribution and antimicrobial susceptibility. RESULTS: The most common serogroup of Shigella isolates was Shigella flexneri (49/98, 50%), followed by Shigella sonnei (44/98, 45%). The highest resistance rate was found for trimethoprim-sulfamethoxazole (81%), followed by tetracycline (74%) and ampicillin (53%). Overall, 76 Shigella isolates (78%) were multidrug-resistant strains; S. flexneri had a higher multidrug resistance rate than S. sonnei (74% vs 23%). Increasing ciprofloxacin and ceftriaxone resistance was observed; approximately 10% and 5% of isolates were resistant to ciprofloxacin and ceftriaxone, respectively. Five ceftriaxone-non-susceptible strains (from Taiwan [3], Hong Kong [1] and The Philippines [1]) and 10 ciprofloxacin-non-susceptible strains (from Hong Kong [2], The Philippines [1], Korea [2], Vietnam [4] and Sri Lanka [1]) were isolated. CONCLUSIONS: High rates of multidrug resistance and steady increases in ceftriaxone and ciprofloxacin resistance of Shigella are serious pubic health concerns in Asian countries. Continuous monitoring of resistance patterns among Shigella isolates is necessary.
Authors: Nhu Thi Khanh Nguyen; Vinh Ha; Nga Vu Thieu Tran; Richard Stabler; Duy Thanh Pham; Thi Minh Vien Le; H Rogier van Doorn; Ana Cerdeño-Tárraga; Nicholas Thomson; James Campbell; Van Minh Hoang Nguyen; Thi Thu Nga Tran; Minh Van Pham; Thuy Thu Cao; Brendan Wren; Jeremy Farrar; Stephen Baker Journal: PLoS Negl Trop Dis Date: 2010-06-08
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Authors: Ha Vinh; Vo Thi Cuc Anh; Nguyen Duc Anh; James I Campbell; Nguyen Van Minh Hoang; Tran Vu Thieu Nga; Nguyen Thi Khanh Nhu; Pham Van Minh; Cao Thu Thuy; Pham Thanh Duy; Le Thi Phuong; Ha Thi Loan; Mai Thu Chinh; Nguyen Thi Thu Thao; Nguyen Thi Hong Tham; Bui Li Mong; Phan Van Be Bay; Jeremy N Day; Christiane Dolecek; Nguyen Phu Huong Lan; To Song Diep; Jeremy J Farrar; Nguyen Van Vinh Chau; Marcel Wolbers; Stephen Baker Journal: PLoS Negl Trop Dis Date: 2011-08-02
Authors: You La Jeon; You-sun Nam; Gayoung Lim; Sun Young Cho; Yun-Tae Kim; Ji-Hyun Jang; Junyoung Kim; Misun Park; Hee Joo Lee Journal: Ann Lab Med Date: 2012-08-13 Impact factor: 3.464