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Literature DB >> 18472938

The effect of steroid treatment on lipocortin immunoreactivity of rat brain.

K G Go¹, J G Ter Haar, L de Ley, F Zuiderveen, L Parente, E Solito, W M Molenaar.

Abstract

Lipocortin-1, lipocortin-2 and lipocortin-5 were immunohistochemically assessed in rats. Apart from animals receiving no treatment, other animals received pretreatment with methylprednisolone, or the 21-aminosteroid U-74389F. Whereas Hpocortin immunoreactivity was absent in the greater part of the brain in animals not pretreated with steroid (except in sporadic microglial cells and choroid plexus), there was obvious immunostaining of parenchymatous elements in steroid pretreated animals. In the steroid pretreated animals lipocortin immunoreactivity of the brain tissue may indicate local formation of lipocortin under the influence of steroids that had entered the tissue. The cellular elements which showed immunostaining included meningeal cells, neurones, ependyma, oligodendroglia and capillary endotheHum.

Entities: Chemical Gene Species

Year: 1994 PMID： 18472938 PMCID： PMC2367041 DOI： 10.1155/S0962935194000232

Source DB: PubMed Journal: Mediators Inflamm ISSN： 0962-9351 Impact factor: 4.711

13 in total

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Authors: P J Strijbos; F J Tilders; F Carey; R Forder; N J Rothwell
Journal: Brain Res Date: 1991-07-12 Impact factor: 3.252

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Journal: Prog Clin Biol Res Date: 1990

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Authors: I Klatzo
Journal: J Neuropathol Exp Neurol Date: 1967-01 Impact factor: 3.685

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Authors: R B Pepinsky; R Tizard; R J Mattaliano; L K Sinclair; G T Miller; J L Browning; E P Chow; C Burne; K S Huang; D Pratt
Journal: J Biol Chem Date: 1988-08-05 Impact factor: 5.157

5. Inhibition of eicosanoid biosynthesis by glucocorticoids in humans.

Authors: R J Sebaldt; J R Sheller; J A Oates; L J Roberts; G A FitzGerald
Journal: Proc Natl Acad Sci U S A Date: 1990-09 Impact factor: 11.205

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Authors: P H Chan; S Longar; R A Fishman
Journal: Brain Res Date: 1983-10-31 Impact factor: 3.252

7. Lipocortin-1 immunoreactivity in the normal human central nervous system and lesions with astrocytosis.

Authors: M D Johnson; J M Kamso-Pratt; W O Whetsell; R B Pepinsky
Journal: Am J Clin Pathol Date: 1989-10 Impact factor: 2.493

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Authors: P H Chan; R A Fishman; J Caronna; J W Schmidley; G Prioleau; J Lee
Journal: Ann Neurol Date: 1983-06 Impact factor: 10.422

9. Dexamethasone induces the expression of the mRNA of lipocortin 1 and 2 and the release of lipocortin 1 and 5 in differentiated, but not undifferentiated U-937 cells.

Authors: E Solito; G Raugei; M Melli; L Parente
Journal: FEBS Lett Date: 1991-10-21 Impact factor: 4.124

3. Induction of annexin-1 at transcriptional and post-transcriptional level in rat brain by methylprednisolone and the 21-aminosteroid U74389F.

Authors: P H Voermans; K G Go; G J Horst; M H Ruiters; E Solito; L Parente
Journal: Mediators Inflamm Date: 1996 Impact factor: 4.711

3 in total