Literature DB >> 6893620

Macrocortin: a polypeptide causing the anti-phospholipase effect of glucocorticoids.

G J Blackwell, R Carnuccio, M Di Rosa, R J Flower, L Parente, P Persico.   

Abstract

Anti-inflammatory glucocorticoids inhibit prostaglandin (PG) biosynthesis by preventing arachidonic acid release from phospholipids rather than inhibiting the cyclooxygenase. As in other cells, this steroid action depends on receptor occupation and de novo protein/RNA biosynthesis. We have previously shown in guinea pig perfused lungs and rat peritoneal leukocytes that the effect of steroids in PG generation is mediated by an uncharacterized 'second messenger'. Now, we report that this factor (which we have named 'macrocortin') is an intracellular polypeptide whose release and synthesis are stimulated by steroids. Macrocortin derived from rat peritoneal leukocytes is very similar to that released from guinea pig lungs.

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Year:  1980        PMID： 6893620     DOI： 10.1038/287147a0

Source DB:  PubMed          Journal:  Nature        ISSN： 0028-0836            Impact factor:   49.962


  166 in total

1.  Autoantibodies to recombinant lipocortin-1 in rheumatoid arthritis and systemic lupus erythematosus.

Authors:  N J Goulding; M R Podgorski; N D Hall; R J Flower; J L Browning; R B Pepinsky; P J Maddison
Journal:  Ann Rheum Dis       Date:  1989-10       Impact factor: 19.103

2.  Monocyte zinc and in vitro prostaglandin E2 and interleukin-1 beta production by cultured peripheral blood monocytes in patients with Crohn's disease.

Authors:  H F Goode; B J Rathbone; J Kelleher; B E Walker
Journal:  Dig Dis Sci       Date:  1991-05       Impact factor: 3.199

Review 3.  Inflammatory intermediaries in inflammatory bowel disease.

Authors:  K Lauritsen; L S Laursen; K Bukhave; J Rask-Madsen
Journal:  Int J Colorectal Dis       Date:  1989       Impact factor: 2.571

Review 4.  Synovial fluid phospholipase A2s and inflammation.

Authors:  H Gonzalez-Buritica; M A Khamashita; G R Hughes
Journal:  Ann Rheum Dis       Date:  1989-04       Impact factor: 19.103

5.  In vivo effects of orally administered prednisolone on prostaglandin and leucotriene production in ulcerative colitis.

Authors:  K Lauritsen; L S Laursen; K Bukhave; J Rask-Madsen
Journal:  Gut       Date:  1987-09       Impact factor: 23.059

6.  Despite a massive increase in cortisol secretion in women during parturition, there is an equally massive increase in prostaglandin synthesis. A paradox?

Authors:  M L Casey; P C MacDonald; M D Mitchell
Journal:  J Clin Invest       Date:  1985-06       Impact factor: 14.808

7.  Effect of dexamethasone on in vivo prostanoid production in the rabbit.

Authors:  A Náray-Fejes-Tóth; G Fejes-Tóth; C Fischer; J C Frölich
Journal:  J Clin Invest       Date:  1984-07       Impact factor: 14.808

8.  Characterization and partial purification of 'renocortins': two polypeptides formed in renal cells causing the anti-phospholipase-like action of glucocorticoids.

Authors:  J F Cloix; O Colard; B Rothhut; F Russo-Marie
Journal:  Br J Pharmacol       Date:  1983-05       Impact factor: 8.739

9.  Presence of autoantibody for phospholipase inhibitory protein, lipomodulin, in patients with rheumatic diseases.

Authors:  F Hirata; R del Carmine; C A Nelson; J Axelrod; E Schiffmann; A Warabi; A L De Blas; M Nirenberg; V Manganiello; M Vaughan; S Kumagai; I Green; J L Decker; A D Steinberg
Journal:  Proc Natl Acad Sci U S A       Date:  1981-05       Impact factor: 11.205

10.  CAF-secreted annexin A1 induces prostate cancer cells to gain stem cell-like features.

Authors:  Lauren A Geary; Kevin A Nash; Helty Adisetiyo; Mengmeng Liang; Chun-Peng Liao; Joseph H Jeong; Ebrahim Zandi; Pradip Roy-Burman
Journal:  Mol Cancer Res       Date:  2014-01-24       Impact factor: 5.852
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