Literature DB >> 1847178

Stabilization of human rhinovirus serotype 2 against pH-induced conformational change by antiviral compounds.

M Gruenberger1, D Pevear, G D Diana, E Kuechler, D Blaas.   

Abstract

Four WIN compounds with anti-picornavirus activities were tested for their ability to stabilize human rhinovirus serotype 2 (HRV-2) against low pH-induced conformational changes in vitro, as determined by specific immunoprecipitation. These results were compared to the minimal inhibitory concentration (MIC) as measured in a plaque reduction assay. A direct relationship was observed between the concentration of the compound that prevented the low pH-induced conformational changes and the MIC, indicating that stabilization is an important element in the mode of action of these drugs against HRV-2.

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Year:  1991        PMID： 1847178     DOI： 10.1099/0022-1317-72-2-431

Source DB:  PubMed          Journal:  J Gen Virol        ISSN： 0022-1317            Impact factor:   3.891


  20 in total

1.  Acid-induced structural changes in human rhinovirus 14: possible role in uncoating.

Authors:  V L Giranda; B A Heinz; M A Oliveira; I Minor; K H Kim; P R Kolatkar; M G Rossmann; R R Rueckert
Journal:  Proc Natl Acad Sci U S A       Date:  1992-11-01       Impact factor: 11.205

2.  Human rhinovirus type 54 infection via heparan sulfate is less efficient and strictly dependent on low endosomal pH.

Authors:  Abdul Ghafoor Khan; Johannes Pichler; Anke Rosemann; Dieter Blaas
Journal:  J Virol       Date:  2007-02-14       Impact factor: 5.103

3.  Major and minor receptor group human rhinoviruses penetrate from endosomes by different mechanisms.

Authors:  D Schober; P Kronenberger; E Prchla; D Blaas; R Fuchs
Journal:  J Virol       Date:  1998-02       Impact factor: 5.103

4.  The cellular receptor to human rhinovirus 2 binds around the 5-fold axis and not in the canyon: a structural view.

Authors:  E A Hewat; E Neumann; J F Conway; R Moser; B Ronacher; T C Marlovits; D Blaas
Journal:  EMBO J       Date:  2000-12-01       Impact factor: 11.598

5.  Uncoating of human rhinovirus serotype 2 from late endosomes.

Authors:  E Prchla; E Kuechler; D Blaas; R Fuchs
Journal:  J Virol       Date:  1994-06       Impact factor: 5.103

6.  WIN 51711-dependent mutants of poliovirus type 3: evidence that virions decay after release from cells unless drug is present.

Authors:  A G Mosser; R R Rueckert
Journal:  J Virol       Date:  1993-03       Impact factor: 5.103

7.  Distribution of drug resistance mutations in type 3 poliovirus identifies three regions involved in uncoating functions.

Authors:  A G Mosser; J Y Sgro; R R Rueckert
Journal:  J Virol       Date:  1994-12       Impact factor: 5.103

8.  Low pH-triggered beta-propeller switch of the low-density lipoprotein receptor assists rhinovirus infection.

Authors:  Tuende Konecsni; Ursula Berka; Angela Pickl-Herk; Gerhard Bilek; Abdul Ghafoor Khan; Leszek Gajdzig; Renate Fuchs; Dieter Blaas
Journal:  J Virol       Date:  2009-08-12       Impact factor: 5.103

9.  Antiviral agent blocks breathing of the common cold virus.

Authors:  J K Lewis; B Bothner; T J Smith; G Siuzdak
Journal:  Proc Natl Acad Sci U S A       Date:  1998-06-09       Impact factor: 11.205

10.  Conformational changes, plasma membrane penetration, and infection by human rhinovirus type 2: role of receptors and low pH.

Authors:  Marianne Brabec; Günther Baravalle; Dieter Blaas; Renate Fuchs
Journal:  J Virol       Date:  2003-05       Impact factor: 5.103
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