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Literature DB >> 1332036

Acid-induced structural changes in human rhinovirus 14: possible role in uncoating.

V L Giranda¹, B A Heinz, M A Oliveira, I Minor, K H Kim, P R Kolatkar, M G Rossmann, R R Rueckert.

Abstract

X-ray diffraction data were collected from human rhinovirus 14 crystals a few minutes after exposure to acid vapor and prior to excessive crystalline disorder. Conformational changes occurred (i) in the GH loop of viral protein (VP) 1, (ii) at the ion binding site on the outer surface of the pentamer center, and (iii) in VP3 and VP4 on the virion's interior in the vicinity of the fivefold axis. Amino acid substitutions in mutants resistant to low pH, or to drugs that inhibit uncoating, were concentrated in the vicinity of the GH loop. It is proposed that the acid-induced changes reflect processes that trigger uncoating.

Entities: Disease Species

Mesh：

Substances：
Capsid Proteins

Year: 1992 PMID： 1332036 PMCID： PMC50308 DOI： 10.1073/pnas.89.21.10213

Source DB: PubMed Journal: Proc Natl Acad Sci U S A ISSN： 0027-8424 Impact factor: 11.205

40 in total

1. The three-dimensional structure of canine parvovirus and its functional implications.

Authors: J Tsao; M S Chapman; M Agbandje; W Keller; K Smith; H Wu; M Luo; T J Smith; M G Rossmann; R W Compans
Journal: Science Date: 1991-03-22 Impact factor: 47.728

2. Human rhinovirus mutants resistant to low pH.

Authors: T Skern; H Torgersen; H Auer; E Kuechler; D Blaas
Journal: Virology Date: 1991-08 Impact factor: 3.616

3. Cell-induced conformational change in poliovirus: externalization of the amino terminus of VP1 is responsible for liposome binding.

Authors: C E Fricks; J M Hogle
Journal: J Virol Date: 1990-05 Impact factor: 5.103

4. Genetic and molecular analyses of spontaneous mutants of human rhinovirus 14 that are resistant to an antiviral compound.

Authors: B A Heinz; R R Rueckert; D A Shepard; F J Dutko; M A McKinlay; M Fancher; M G Rossmann; J Badger; T J Smith
Journal: J Virol Date: 1989-06 Impact factor: 5.103

5. Crystal structure of human rhinovirus serotype 1A (HRV1A).

Authors: S S Kim; T J Smith; M S Chapman; M C Rossmann; D C Pevear; F J Dutko; P J Felock; G D Diana; M A McKinlay
Journal: J Mol Biol Date: 1989-11-05 Impact factor: 5.469

6. Conservation of the putative receptor attachment site in picornaviruses.

Authors: M G Rossmann; A C Palmenberg
Journal: Virology Date: 1988-06 Impact factor: 3.616

7. A cell adhesion molecule, ICAM-1, is the major surface receptor for rhinoviruses.

Authors: D E Staunton; V J Merluzzi; R Rothlein; R Barton; S D Marlin; T A Springer
Journal: Cell Date: 1989-03-10 Impact factor: 41.582

8. Neutralization of poliovirus by cell receptors expressed in insect cells.

Authors: G Kaplan; M S Freistadt; V R Racaniello
Journal: J Virol Date: 1990-10 Impact factor: 5.103

9. Divalent cation sites in tomato bushy stunt virus. Difference maps at 2-9 A resolution.

Authors: J Hogle; T Kirchhausen; S C Harrison
Journal: J Mol Biol Date: 1983-11-25 Impact factor: 5.469

10. Different pH requirements for entry of the two picornaviruses, human rhinovirus 2 and murine encephalomyocarditis virus.

Authors: I H Madshus; S Olsnes; K Sandvig
Journal: Virology Date: 1984-12 Impact factor: 3.616

30 in total

1. Seneca Valley virus attachment and uncoating mediated by its receptor anthrax toxin receptor 1.

Authors: Lin Cao; Ran Zhang; Tingting Liu; Zixian Sun; Mingxu Hu; Yuna Sun; Lingpeng Cheng; Yu Guo; Sheng Fu; Junjie Hu; Xiangmin Li; Chengqi Yu; Hanyang Wang; Huanchun Chen; Xueming Li; Elizabeth E Fry; David I Stuart; Ping Qian; Zhiyong Lou; Zihe Rao
Journal: Proc Natl Acad Sci U S A Date: 2018-12-04 Impact factor: 11.205

Review 2. Picornavirus uncoating.

Authors: M S Smyth; J H Martin
Journal: Mol Pathol Date: 2002-08

Acid-induced structural changes in human rhinovirus 14: possible role in uncoating.

1. The three-dimensional structure of canine parvovirus and its functional implications.

2. Human rhinovirus mutants resistant to low pH.

3. Cell-induced conformational change in poliovirus: externalization of the amino terminus of VP1 is responsible for liposome binding.

4. Genetic and molecular analyses of spontaneous mutants of human rhinovirus 14 that are resistant to an antiviral compound.

5. Crystal structure of human rhinovirus serotype 1A (HRV1A).

6. Conservation of the putative receptor attachment site in picornaviruses.

7. A cell adhesion molecule, ICAM-1, is the major surface receptor for rhinoviruses.

8. Neutralization of poliovirus by cell receptors expressed in insect cells.

9. Divalent cation sites in tomato bushy stunt virus. Difference maps at 2-9 A resolution.

10. Different pH requirements for entry of the two picornaviruses, human rhinovirus 2 and murine encephalomyocarditis virus.

1. Seneca Valley virus attachment and uncoating mediated by its receptor anthrax toxin receptor 1.

Review 2. Picornavirus uncoating.

3. Molecular basis for the acid-initiated uncoating of human enterovirus D68.

4. Primary changes of the mechanical properties of Southern Bean Mosaic Virus upon calcium removal.

5. An externalized polypeptide partitions between two distinct sites on genome-released poliovirus particles.

6. Long-distance correlations of rhinovirus capsid dynamics contribute to uncoating and antiviral activity.

7. Role of sialyloligosaccharide binding in Theiler's virus persistence.

8. Canine parvovirus host range is determined by the specific conformation of an additional region of the capsid.

9. Conformational shift of a major poliovirus antigen confirmed by immuno-cryogenic electron microscopy.

10. Crystal structure of Swine vesicular disease virus and implications for host adaptation.