OBJECTIVE: Evidence demonstrates that occupational exposures are causally linked with chronic obstructive pulmonary disease (COPD). This case-control study evaluated the association between occupational exposures and prevalent COPD based on lifetime occupational history. METHODS: Cases (n = 388) aged 45 years and older with COPD were compared with controls (n = 356), frequency matched on age, sex, and cigarette smoking history. Odds ratios for exposure to each of eight occupational hazard categories and three composite measures of exposure were computed using logistic regression. RESULTSOccupational exposures most strongly associated with COPD were diesel exhaust, irritant gases and vapors, mineral dust, and metal dust. The composite measures describing aggregate exposure to gases, vapors, solvents, or sensitizers (GVSS) and aggregate exposure to dust, GVSS, or diesel exhaust were also associated with COPD. In the small group of never-smokers, a similar pattern was evident. CONCLUSION: These population-based findings add to the literature linking occupational exposures to COPD.
OBJECTIVE: Evidence demonstrates that occupational exposures are causally linked with chronic obstructive pulmonary disease (COPD). This case-control study evaluated the association between occupational exposures and prevalent COPD based on lifetime occupational history. METHODS: Cases (n = 388) aged 45 years and older with COPD were compared with controls (n = 356), frequency matched on age, sex, and cigarette smoking history. Odds ratios for exposure to each of eight occupational hazard categories and three composite measures of exposure were computed using logistic regression. RESULTSOccupational exposures most strongly associated with COPD were diesel exhaust, irritant gases and vapors, mineral dust, and metal dust. The composite measures describing aggregate exposure to gases, vapors, solvents, or sensitizers (GVSS) and aggregate exposure to dust, GVSS, or diesel exhaust were also associated with COPD. In the small group of never-smokers, a similar pattern was evident. CONCLUSION: These population-based findings add to the literature linking occupational exposures to COPD.
Authors: P J Quinlan; G Earnest; M D Eisner; E H Yelin; P P Katz; J R Balmes; P D Blanc Journal: Occup Environ Med Date: 2008-09-19 Impact factor: 4.402
Authors: Brent Doney; Eva Hnizdo; Monica Graziani; Greg Kullman; Cecil Burchfiel; Sherry Baron; Kaori Fujishiro; Paul Enright; John L Hankinson; Karen Hinckley Stukovsky; Christopher J Martin; Kathleen M Donohue; R Graham Barr Journal: COPD Date: 2014-02-25 Impact factor: 2.409
Authors: Nathaniel Marchetti; Eric Garshick; Gregory L Kinney; Alex McKenzie; Douglas Stinson; Sharon M Lutz; David A Lynch; Gerard J Criner; Edwin K Silverman; James D Crapo Journal: Am J Respir Crit Care Med Date: 2014-10-01 Impact factor: 21.405