| Literature DB >> 1846917 |
D T Chu1, C W Nordeen, D J Hardy, R N Swanson, W J Giardina, A G Pernet, J J Plattner.
Abstract
Temafloxacin hydrochloride [(+/-)-7-(3-methylpiperazin-1-yl)-6-fluoro-1-(2,4-difluorophenyl)- 1,4-dihydro- 4-oxoquinoline-3-carboxylic acid hydrochloride] is a potent member of the 4-pyridone-3-carboxylic acid class of antibacterial agents and is currently under clinical development as a broad-spectrum antimicrobial agent. It is a racemate having a chiral center at the C3 of the 7-piperazin-1-yl group. The two enantiomers were synthesized and tested for their antibacterial activities. Although no difference in in vitro antibacterial activities was observed, a minor difference in in vivo antibacterial activities was observed. However, they both exhibited similar pharmacological profiles.Entities:
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Year: 1991 PMID： 1846917 DOI： 10.1021/jm00105a025
Source DB: PubMed Journal: J Med Chem ISSN： 0022-2623 Impact factor: 7.446