Literature DB >> 18468893

Improved synthesis of antibacterial 3-substituted 6-anilinouracils.

Niels Svenstrup1, Alexander Kuhl, Kerstin Ehlert, Dieter Häbich.   

Abstract

3-Substituted 6-anilinouracils, presently the most promising class of inhibitors of the bacterial DNA polymerase in Gram-positive bacteria, have been prepared by a general and straightforward three-step procedure starting from a readily available 1-benzyloxymethyl-protected derivative of 6-chlorouracil.

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Year:  2008        PMID: 18468893     DOI: 10.1016/j.bmcl.2008.04.061

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN: 0960-894X            Impact factor:   2.823


  1 in total

1.  2-Chloro-8-methyl-3-[(pyrimidin-4-yl-oxy)meth-yl]quinoline.

Authors:  F Nawaz Khan; S Mohana Roopan; Venkatesha R Hathwar; Mehmet Akkurt
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2010-04-02
  1 in total

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