Literature DB >> 1846704

The myoD gene family: nodal point during specification of the muscle cell lineage.

H Weintraub1, R Davis, S Tapscott, M Thayer, M Krause, R Benezra, T K Blackwell, D Turner, R Rupp, S Hollenberg.   

Abstract

The myoD gene converts many differentiated cell types into muscle. MyoD is a member of the basic-helix-loop-helix family of proteins; this 68-amino acid domain in MyoD is necessary and sufficient for myogenesis. MyoD binds cooperatively to muscle-specific enhancers and activates transcription. The helix-loop-helix motif is responsible for dimerization, and, depending on its dimerization partner, MyoD activity can be controlled. MyoD senses and integrates many facets of cell state. MyoD is expressed only in skeletal muscle and its precursors; in nonmuscle cells myoD is repressed by specific genes. MyoD activates its own transcription; this may stabilize commitment to myogenesis.

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Year:  1991        PMID： 1846704     DOI： 10.1126/science.1846704

Source DB:  PubMed          Journal:  Science        ISSN： 0036-8075            Impact factor:   47.728


  424 in total

1.  Degradation of MyoD by the ubiquitin pathway: regulation by specific DNA-binding and identification of a novel site for ubiquitination.

Authors:  A Ciechanover; K Breitschopf; O A Hatoum; E Bengal
Journal:  Mol Biol Rep       Date:  1999-04       Impact factor: 2.316

2.  zfh-1, the Drosophila homologue of ZEB, is a transcriptional repressor that regulates somatic myogenesis.

Authors:  A A Postigo; E Ward; J B Skeath; D C Dean
Journal:  Mol Cell Biol       Date:  1999-10       Impact factor: 4.272

3.  Establishment of distinct MyoD, E2A, and twist DNA binding specificities by different basic region-DNA conformations.

Authors:  T Kophengnavong; J E Michnowicz; T K Blackwell
Journal:  Mol Cell Biol       Date:  2000-01       Impact factor: 4.272

4.  The myogenic regulatory circuit that controls cardiac/slow twitch troponin C gene transcription in skeletal muscle involves E-box, MEF-2, and MEF-3 motifs.

Authors:  T H Christensen; L Kedes
Journal:  Gene Expr       Date:  1999

5.  Synergistic regulation of vertebrate muscle development by Dach2, Eya2, and Six1, homologs of genes required for Drosophila eye formation.

Authors:  T A Heanue; R Reshef; R J Davis; G Mardon; G Oliver; S Tomarev; A B Lassar; C J Tabin
Journal:  Genes Dev       Date:  1999-12-15       Impact factor: 11.361

6.  Alteration of the levels of the M-type 6-phosphofructo-1-kinase mRNA isoforms during neonatal maturation of heart, brain and muscle.

Authors:  Y Mhaskar; G Armour; G Dunaway
Journal:  Mol Cell Biochem       Date:  2000-11       Impact factor: 3.396

7.  Glucocorticoid inhibition of C2C12 proliferation rate and differentiation capacity in relation to mRNA levels of the MRF gene family.

Authors:  M F te Pas; P R de Jong; F J Verburg
Journal:  Mol Biol Rep       Date:  2000-06       Impact factor: 2.316

8.  Lactation defect in mice lacking the helix-loop-helix inhibitor Id2.

Authors:  S Mori; S I Nishikawa; Y Yokota
Journal:  EMBO J       Date:  2000-11-01       Impact factor: 11.598

Review 9.  Class II transactivator: mastering the art of major histocompatibility complex expression.

Authors:  J A Harton; J P Ting
Journal:  Mol Cell Biol       Date:  2000-09       Impact factor: 4.272

10.  Noninvasive quantitative imaging of protein-protein interactions in living subjects.

Authors:  P Ray; H Pimenta; R Paulmurugan; F Berger; M E Phelps; M Iyer; S S Gambhir
Journal:  Proc Natl Acad Sci U S A       Date:  2002-02-19       Impact factor: 11.205
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