BACKGROUND: Few prospective data link early childhood adiposity with asthma-related symptoms. OBJECTIVE: We sought to examine the associations of weight-for-length (WFL) at age 6 months with incidence of wheezing by age 3 years. METHODS: We studied 932 children in a prospective cohort of children. The main outcome was recurrent wheezing, which was defined as parents' report of wheezing between 2 and 3 years of age plus wheezing in either year 1 or 2 of life. Secondary outcomes included any wheezing from 6 months to 3 years and current asthma. We used multiple logistic regression to examine associations of 6-month WFL z scores with these outcomes. RESULTS: At 6 months, the infants' mean WFL z score was 0.68 (SD, 0.94; range -2.96 to 3.24). By age 3 years, 14% of children had recurrent wheezing. After adjustment for a variety of potential confounders, we found that each 1-unit increment in 6-month WFL z score was associated with greater odds of recurrent wheezing (odds ratio [OR], 1.46; 95% CI, 1.11-1.91) and any wheezing (OR, 1.23; 95% CI, 1.03-1.48). We observed a weaker association between 6-month WFL z score and current asthma (OR, 1.22; 95% CI, 0.94-1.59). CONCLUSION: Infants with higher WFL z scores at 6 months of age had a greater risk of recurrent wheezing by age 3 years. It is unclear whether the relationship of infant adiposity and early-life wheeze extends to allergic asthma or wheeze that can persist into later childhood. Our findings suggest that early interventions to prevent excess infant adiposity might help reduce children's risk of asthma-related symptoms.
BACKGROUND: Few prospective data link early childhood adiposity with asthma-related symptoms. OBJECTIVE: We sought to examine the associations of weight-for-length (WFL) at age 6 months with incidence of wheezing by age 3 years. METHODS: We studied 932 children in a prospective cohort of children. The main outcome was recurrent wheezing, which was defined as parents' report of wheezing between 2 and 3 years of age plus wheezing in either year 1 or 2 of life. Secondary outcomes included any wheezing from 6 months to 3 years and current asthma. We used multiple logistic regression to examine associations of 6-month WFL z scores with these outcomes. RESULTS: At 6 months, the infants' mean WFL z score was 0.68 (SD, 0.94; range -2.96 to 3.24). By age 3 years, 14% of children had recurrent wheezing. After adjustment for a variety of potential confounders, we found that each 1-unit increment in 6-month WFL z score was associated with greater odds of recurrent wheezing (odds ratio [OR], 1.46; 95% CI, 1.11-1.91) and any wheezing (OR, 1.23; 95% CI, 1.03-1.48). We observed a weaker association between 6-month WFL z score and current asthma (OR, 1.22; 95% CI, 0.94-1.59). CONCLUSION:Infants with higher WFL z scores at 6 months of age had a greater risk of recurrent wheezing by age 3 years. It is unclear whether the relationship of infant adiposity and early-life wheeze extends to allergic asthma or wheeze that can persist into later childhood. Our findings suggest that early interventions to prevent excess infant adiposity might help reduce children's risk of asthma-related symptoms.
Authors: J A Castro-Rodríguez; C J Holberg; W J Morgan; A L Wright; F D Martinez Journal: Am J Respir Crit Care Med Date: 2001-05 Impact factor: 21.405
Authors: Allison A Hedley; Cynthia L Ogden; Clifford L Johnson; Margaret D Carroll; Lester R Curtin; Katherine M Flegal Journal: JAMA Date: 2004-06-16 Impact factor: 56.272
Authors: Stuart P Weisberg; Daniel McCann; Manisha Desai; Michael Rosenbaum; Rudolph L Leibel; Anthony W Ferrante Journal: J Clin Invest Date: 2003-12 Impact factor: 14.808
Authors: Don D Sin; Sheldon Spier; Larry W Svenson; Don P Schopflocher; Ambikaipakan Senthilselvan; Robert L Cowie; S F Paul Man Journal: Arch Pediatr Adolesc Med Date: 2004-01
Authors: Sara E Benjamin; Elsie M Taveras; Angie L Cradock; Elizabeth M Walker; Meghan M Slining; Matthew W Gillman Journal: Pediatrics Date: 2009-07 Impact factor: 7.124
Authors: Emily Oken; Andrea A Baccarelli; Diane R Gold; Ken P Kleinman; Augusto A Litonjua; Dawn De Meo; Janet W Rich-Edwards; Sheryl L Rifas-Shiman; Sharon Sagiv; Elsie M Taveras; Scott T Weiss; Mandy B Belfort; Heather H Burris; Carlos A Camargo; Susanna Y Huh; Christos Mantzoros; Margaret G Parker; Matthew W Gillman Journal: Int J Epidemiol Date: 2014-03-16 Impact factor: 7.196
Authors: Ellen Perkins; Susan K Murphy; Amy P Murtha; Joellen Schildkraut; Randy L Jirtle; Wendy Demark-Wahnefried; Michele R Forman; Joanne Kurtzberg; Francine Overcash; Zhiqing Huang; Cathrine Hoyo Journal: J Pediatr Date: 2012-02-17 Impact factor: 4.406
Authors: Nancy E Lange; Sheryl L Rifas-Shiman; Carlos A Camargo; Diane R Gold; Matthew W Gillman; Augusto A Litonjua Journal: J Allergy Clin Immunol Date: 2010-06-26 Impact factor: 10.793
Authors: Erick Forno; Rachel Lescher; Robert Strunk; Scott Weiss; Anne Fuhlbrigge; Juan C Celedón Journal: J Allergy Clin Immunol Date: 2011-03 Impact factor: 10.793
Authors: Sara E Benjamin Neelon; Hortensia Reyes-Morales; Jess Haines; Matthew W Gillman; Elsie M Taveras Journal: Public Health Nutr Date: 2012-10-04 Impact factor: 4.022
Authors: Diane R Gold; Gordon R Bloomberg; William W Cruikshank; Cynthia M Visness; John Schwarz; Meyer Kattan; George T O'Connor; Robert A Wood; Melissa S Burger; Rosalind J Wright; Frank Witter; Aviva Lee-Parritz; Rhoda Sperling; Yoel Sadovsky; Alkis Togias; James E Gern Journal: J Allergy Clin Immunol Date: 2009-11 Impact factor: 10.793