Literature DB >> 1846672

Myristylation alters DNA-binding activity and transactivation of FBR (gag-fos) protein.

N Kamata1, R M Jotte, J T Holt.   

Abstract

FBR murine sarcoma virus (gag-fos) protein, a virally transduced Fos protein, exhibits decreased gene transactivation in comparison with the cellular Fos protein. Biochemical analysis suggests that myristylation of the virally encoded N-terminal gag region results in decreased DNA binding and transcriptional activation without affecting heterodimerization with Jun protein. These findings demonstrate that protein myristylation can modulate gene regulation by a DNA-binding protein.

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Year:  1991        PMID： 1846672      PMCID： PMC359728          DOI： 10.1128/mcb.11.2.765-772.1991

Source DB:  PubMed          Journal:  Mol Cell Biol        ISSN： 0270-7306            Impact factor:   4.272


  45 in total

Review 1.  Human proto-oncogene c-jun encodes a DNA binding protein with structural and functional properties of transcription factor AP-1.

Authors:  D Bohmann; T J Bos; A Admon; T Nishimura; P K Vogt; R Tjian
Journal:  Science       Date:  1987-12-04       Impact factor: 47.728

2.  Specific and saturable binding of pp60v-src to plasma membranes: evidence for a myristyl-src receptor.

Authors:  M D Resh
Journal:  Cell       Date:  1989-07-28       Impact factor: 41.582

3.  The mouse type IV c-abl gene product is a nuclear protein, and activation of transforming ability is associated with cytoplasmic localization.

Authors:  R A Van Etten; P Jackson; D Baltimore
Journal:  Cell       Date:  1989-08-25       Impact factor: 41.582

4.  Growth factors regulate transin gene expression by c-fos-dependent and c-fos-independent pathways.

Authors:  L D Kerr; J T Holt; L M Matrisian
Journal:  Science       Date:  1988-12-09       Impact factor: 47.728

5.  Phosphorylation-induced binding and transcriptional efficacy of nuclear factor CREB.

Authors:  K K Yamamoto; G A Gonzalez; W H Biggs; M R Montminy
Journal:  Nature       Date:  1988-08-11       Impact factor: 49.962

6.  Phorbol ester-inducible genes contain a common cis element recognized by a TPA-modulated trans-acting factor.

Authors:  P Angel; M Imagawa; R Chiu; B Stein; R J Imbra; H J Rahmsdorf; C Jonat; P Herrlich; M Karin
Journal:  Cell       Date:  1987-06-19       Impact factor: 41.582

7.  Requirement for fos gene expression in the transcriptional activation of collagenase by other oncogenes and phorbol esters.

Authors:  A Schönthal; P Herrlich; H J Rahmsdorf; H Ponta
Journal:  Cell       Date:  1988-07-29       Impact factor: 41.582

8.  Virus induction of osteosarcomas in mice.

Authors:  M P Finkel; B O Biskis; P B Jinkins
Journal:  Science       Date:  1966-02-11       Impact factor: 47.728

9.  In vitro synthesis of pp60v-src: myristylation in a cell-free system.

Authors:  I Deichaite; L P Casson; H P Ling; M D Resh
Journal:  Mol Cell Biol       Date:  1988-10       Impact factor: 4.272

10.  Mutation of NH2-terminal glycine of p60src prevents both myristoylation and morphological transformation.

Authors:  M P Kamps; J E Buss; B M Sefton
Journal:  Proc Natl Acad Sci U S A       Date:  1985-07       Impact factor: 11.205
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  9 in total

1.  Neurotrophic protein S100 beta stimulates glial cell proliferation.

Authors:  R H Selinfreund; S W Barger; W J Pledger; L J Van Eldik
Journal:  Proc Natl Acad Sci U S A       Date:  1991-05-01       Impact factor: 11.205

2.  Isolation of an AP-1 repressor by a novel method for detecting protein-protein interactions.

Authors:  A Aronheim; E Zandi; H Hennemann; S J Elledge; M Karin
Journal:  Mol Cell Biol       Date:  1997-06       Impact factor: 4.272

3.  Antisense rescue defines specialized and generalized functional domains for c-Fos protein.

Authors:  J T Holt
Journal:  Mol Cell Biol       Date:  1993-06       Impact factor: 4.272

4.  Myristylation of Pr60gag of the murine AIDS-defective virus is required to induce disease and notably for the expansion of its target cells.

Authors:  M Huang; P Jolicoeur
Journal:  J Virol       Date:  1994-09       Impact factor: 5.103

5.  gag as well as myc sequences contribute to the transforming phenotype of the avian retrovirus FH3.

Authors:  A T Tikhonenko; M L Linial
Journal:  J Virol       Date:  1992-02       Impact factor: 5.103

6.  MGSA/GRO transcription is differentially regulated in normal retinal pigment epithelial and melanoma cells.

Authors:  R L Shattuck; L D Wood; G J Jaffe; A Richmond
Journal:  Mol Cell Biol       Date:  1994-01       Impact factor: 4.272

7.  Inhibitory effect of myristylation on transrepression by FBR (Gag-Fos) protein.

Authors:  N Kamata; J T Holt
Journal:  Mol Cell Biol       Date:  1992-02       Impact factor: 4.272

8.  Phosphatidylinositol 3-kinase/Akt signaling enhances nuclear localization and transcriptional activity of BRCA1.

Authors:  Cimona V Hinton; Latricia D Fitzgerald; Marilyn E Thompson
Journal:  Exp Cell Res       Date:  2007-03-15       Impact factor: 3.905

9.  Myristylation of FBR v-fos dictates the differentiation pathways in malignant osteosarcoma.

Authors:  R M Jotte; J T Holt
Journal:  J Cell Biol       Date:  1996-10       Impact factor: 10.539
  9 in total

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