Literature DB >> 1846490

Viral cytopathogenicity correlated with integration of ubiquitin-coding sequences.

G Meyers1, N Tautz, E J Dubovi, H J Thiel.   

Abstract

The RNA genomes of cytopathogenic bovine viral diarrhea virus (BVDV) isolates contain insertions highly homologous to cellular sequences. For two of them the insert was identified as ubiquitin coding sequence. The genome of BVDV Osloss contains exactly one ubiquitin gene monomer. In the case of BVDV CP1 the cellular insertion comprises one complete ubiquitin gene and part of a second monomer. The host cell-derived element in the CP1 genome is embedded in a large duplication of about 2.4 kb of viral sequences. Cellular insertion and duplication were not found in the genome of NCP1, the noncytopathogenic counterpart of CP1. These results strongly suggest that recombination between viral and cellular RNA is responsible for development of the cytopathogenic viruses, which is linked to pathogenesis of a lethal disease in cattle.

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Year:  1991        PMID： 1846490      PMCID： PMC7172395          DOI： 10.1016/0042-6822(91)90074-l

Source DB:  PubMed          Journal:  Virology        ISSN： 0042-6822            Impact factor:   3.616


  45 in total

1.  Ubiquitin in a togavirus.

Authors:  G Meyers; T Rümenapf; H J Thiel
Journal:  Nature       Date:  1989-10-12       Impact factor: 49.962

2.  Cleavage of structural proteins during the assembly of the head of bacteriophage T4.

Authors:  U K Laemmli
Journal:  Nature       Date:  1970-08-15       Impact factor: 49.962

3.  Unidirectional digestion with exonuclease III in DNA sequence analysis.

Authors:  S Henikoff
Journal:  Methods Enzymol       Date:  1987       Impact factor: 1.600

4.  Variation in the intracellular polypeptide profiles from different isolates of bovine virus diarrhoea virus.

Authors:  D H Pocock; C J Howard; M C Clarke; J Brownlie
Journal:  Arch Virol       Date:  1987       Impact factor: 2.574

5.  Experimental production of fatal mucosal disease in cattle.

Authors:  J Brownlie; M C Clarke; C J Howard
Journal:  Vet Rec       Date:  1984-06-02       Impact factor: 2.695

6.  Rift Valley fever virus M segment: cell-free transcription and translation of virus-complementary RNA.

Authors:  J A Suzich; M S Collett
Journal:  Virology       Date:  1988-06       Impact factor: 3.616

7.  DNA sequencing with chain-terminating inhibitors.

Authors:  F Sanger; S Nicklen; A R Coulson
Journal:  Proc Natl Acad Sci U S A       Date:  1977-12       Impact factor: 11.205

8.  Molecular specificity of the antibody responses of cattle naturally and experimentally infected with cytopathic and noncytopathic bovine viral diarrhea virus biotypes.

Authors:  R O Donis; E J Dubovi
Journal:  Am J Vet Res       Date:  1987-11       Impact factor: 1.156

9.  Monoclonal antibody analyses of cytopathic and noncytopathic viruses from fatal bovine viral diarrhea virus infections.

Authors:  W V Corapi; R O Donis; E J Dubovi
Journal:  J Virol       Date:  1988-08       Impact factor: 5.103

10.  Proteins encoded by bovine viral diarrhea virus: the genomic organization of a pestivirus.

Authors:  M S Collett; R Larson; S K Belzer; E Retzel
Journal:  Virology       Date:  1988-07       Impact factor: 3.616
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  69 in total

1.  A cellular J-domain protein modulates polyprotein processing and cytopathogenicity of a pestivirus.

Authors:  G Rinck; C Birghan; T Harada; G Meyers; H J Thiel; N Tautz
Journal:  J Virol       Date:  2001-10       Impact factor: 5.103

2.  CRISPR/Cas9-Mediated Knockout of DNAJC14 Verifies This Chaperone as a Pivotal Host Factor for RNA Replication of Pestiviruses.

Authors:  O Isken; A Postel; B Bruhn; E Lattwein; P Becher; N Tautz
Journal:  J Virol       Date:  2019-02-19       Impact factor: 5.103

Review 3.  Viral evolution and emerging viral infections: what future for the viruses? A theoretical evaluation based on informational spaces and quasispecies.

Authors:  Hugues Tolou; Jean Nicoli; Claude Chastel
Journal:  Virus Genes       Date:  2002-06       Impact factor: 2.332

Review 4.  [Ubiquitin-dependent degradation and modification of proteins].

Authors:  J von Kampen; M Wettern
Journal:  Naturwissenschaften       Date:  1992-04

5.  Adaptation of a genotype 3 hepatitis E virus to efficient growth in cell culture depends on an inserted human gene segment acquired by recombination.

Authors:  P Shukla; H T Nguyen; K Faulk; K Mather; U Torian; R E Engle; S U Emerson
Journal:  J Virol       Date:  2012-03-07       Impact factor: 5.103

6.  New nucleotide sequence data on the EMBL File Server.

Authors: 
Journal:  Nucleic Acids Res       Date:  1991-05-25       Impact factor: 16.971

7.  Recombination between Sindbis virus RNAs.

Authors:  B G Weiss; S Schlesinger
Journal:  J Virol       Date:  1991-08       Impact factor: 5.103

8.  Correlation between point mutations in NS2 and the viability and cytopathogenicity of Bovine viral diarrhea virus strain Oregon analyzed with an infectious cDNA clone.

Authors:  B M Kümmerer; G Meyers
Journal:  J Virol       Date:  2000-01       Impact factor: 5.103

9.  Pestiviruses isolated from pigs, cattle and sheep can be allocated into at least three genogroups using polymerase chain reaction and restriction endonuclease analysis.

Authors:  S Vilcek; A J Herring; J A Herring; P F Nettleton; J P Lowings; D J Paton
Journal:  Arch Virol       Date:  1994       Impact factor: 2.574

Review 10.  Bovine viral diarrhea virus: biotypes and disease.

Authors:  D Deregt; K G Loewen
Journal:  Can Vet J       Date:  1995-06       Impact factor: 1.008
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