| Literature DB >> 18464734 |
Wesley C Warren1, LaDeana W Hillier, Jennifer A Marshall Graves, Ewan Birney, Chris P Ponting, Frank Grützner, Katherine Belov, Webb Miller, Laura Clarke, Asif T Chinwalla, Shiaw-Pyng Yang, Andreas Heger, Devin P Locke, Pat Miethke, Paul D Waters, Frédéric Veyrunes, Lucinda Fulton, Bob Fulton, Tina Graves, John Wallis, Xose S Puente, Carlos López-Otín, Gonzalo R Ordóñez, Evan E Eichler, Lin Chen, Ze Cheng, Janine E Deakin, Amber Alsop, Katherine Thompson, Patrick Kirby, Anthony T Papenfuss, Matthew J Wakefield, Tsviya Olender, Doron Lancet, Gavin A Huttley, Arian F A Smit, Andrew Pask, Peter Temple-Smith, Mark A Batzer, Jerilyn A Walker, Miriam K Konkel, Robert S Harris, Camilla M Whittington, Emily S W Wong, Neil J Gemmell, Emmanuel Buschiazzo, Iris M Vargas Jentzsch, Angelika Merkel, Juergen Schmitz, Anja Zemann, Gennady Churakov, Jan Ole Kriegs, Juergen Brosius, Elizabeth P Murchison, Ravi Sachidanandam, Carly Smith, Gregory J Hannon, Enkhjargal Tsend-Ayush, Daniel McMillan, Rosalind Attenborough, Willem Rens, Malcolm Ferguson-Smith, Christophe M Lefèvre, Julie A Sharp, Kevin R Nicholas, David A Ray, Michael Kube, Richard Reinhardt, Thomas H Pringle, James Taylor, Russell C Jones, Brett Nixon, Jean-Louis Dacheux, Hitoshi Niwa, Yoko Sekita, Xiaoqiu Huang, Alexander Stark, Pouya Kheradpour, Manolis Kellis, Paul Flicek, Yuan Chen, Caleb Webber, Ross Hardison, Joanne Nelson, Kym Hallsworth-Pepin, Kim Delehaunty, Chris Markovic, Pat Minx, Yucheng Feng, Colin Kremitzki, Makedonka Mitreva, Jarret Glasscock, Todd Wylie, Patricia Wohldmann, Prathapan Thiru, Michael N Nhan, Craig S Pohl, Scott M Smith, Shunfeng Hou, Mikhail Nefedov, Pieter J de Jong, Marilyn B Renfree, Elaine R Mardis, Richard K Wilson.
Abstract
We present a draft genome sequence of the platypus, Ornithorhynchus anatinus. This monotreme exhibits a fascinating combination of reptilian and mammalian characters. For example, platypuses have a coat of fur adapted to an aquatic lifestyle; platypus females lactate, yet lay eggs; and males are equipped with venom similar to that of reptiles. Analysis of the first monotreme genome aligned these features with genetic innovations. We find that reptile and platypus venom proteins have been co-opted independently from the same gene families; milk protein genes are conserved despite platypuses laying eggs; and immune gene family expansions are directly related to platypus biology. Expansions of protein, non-protein-coding RNA and microRNA families, as well as repeat elements, are identified. Sequencing of this genome now provides a valuable resource for deep mammalian comparative analyses, as well as for monotreme biology and conservation.Entities:
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Year: 2008 PMID： 18464734 PMCID： PMC2803040 DOI： 10.1038/nature06936
Source DB: PubMed Journal: Nature ISSN： 0028-0836 Impact factor: 49.962