| Literature DB >> 18458459 |
Y T Wei1, W M Tian, X Yu, F Z Cui, S P Hou, Q Y Xu, In-Seop Lee.
Abstract
A biocompatible hydrogel of hyaluronic acid with the neurite-promoting peptide sequence of IKVAV was synthesized. The characterization of the hydrogel shows an open porous structure and a large surface area available for cell interaction. Its ability to promote tissue repair and axonal regeneration in the lesioned rat cerebrum is also evaluated. After implantation, the polymer hydrogel repaired the tissue defect and formed a permissive interface with the host tissue. Axonal growth occurred within the microstructure of the network. Within 6 weeks the polymer implant was invaded by host-derived tissue, glial cells, blood vessels and axons. Such a hydrogel matrix showed the properties of neuron conduction. It has the potential to repair tissue defects in the central nervous system by promoting the formation of a tissue matrix and axonal growth by replacing the lost tissue.Entities:
Mesh：
Substances：
Year: 2007 PMID： 18458459 DOI： 10.1088/1748-6041/2/3/S11
Source DB: PubMed Journal: Biomed Mater ISSN： 1748-6041 Impact factor: 3.715