Literature DB >> 29344975

Extracellular matrix and traumatic brain injury.

Naijil George1, Herbert M Geller1.   

Abstract

The brain extracellular matrix (ECM) plays a crucial role in both the developing and adult brain by providing structural support and mediating cell-cell interactions. In this review, we focus on the major constituents of the ECM and how they function in both normal and injured brain, and summarize the changes in the composition of the ECM as well as how these changes either promote or inhibit recovery of function following traumatic brain injury (TBI). Modulation of ECM composition to facilitates neuronal survival, regeneration and axonal outgrowth is a potential therapeutic target for TBI treatment. Published 2018. This article is a U.S. Government work and is in the public domain in the USA.

Entities:  

Keywords:  hyaluronan; laminin; metalloprotease; proteoglycans; tenascin

Mesh:

Substances:

Year:  2018        PMID: 29344975      PMCID: PMC5803383          DOI: 10.1002/jnr.24151

Source DB:  PubMed          Journal:  J Neurosci Res        ISSN: 0360-4012            Impact factor:   4.164


  218 in total

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