| Literature DB >> 29344975 |
Naijil George1, Herbert M Geller1.
Abstract
The brain extracellular matrix (ECM) plays a crucial role in both the developing and adult brain by providing structural support and mediating cell-cell interactions. In this review, we focus on the major constituents of the ECM and how they function in both normal and injured brain, and summarize the changes in the composition of the ECM as well as how these changes either promote or inhibit recovery of function following traumatic brain injury (TBI). Modulation of ECM composition to facilitates neuronal survival, regeneration and axonal outgrowth is a potential therapeutic target for TBI treatment. Published 2018. This article is a U.S. Government work and is in the public domain in the USA.Entities:
Keywords: hyaluronan; laminin; metalloprotease; proteoglycans; tenascin
Mesh:
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Year: 2018 PMID: 29344975 PMCID: PMC5803383 DOI: 10.1002/jnr.24151
Source DB: PubMed Journal: J Neurosci Res ISSN: 0360-4012 Impact factor: 4.164