Literature DB >> 18457385

Recent developments in fragment-based drug discovery.

Miles Congreve1, Gianni Chessari, Dominic Tisi, Andrew J Woodhead.   

Abstract

Mesh：

Substances：

Year:  2008        PMID： 18457385     DOI： 10.1021/jm8000373

Source DB:  PubMed          Journal:  J Med Chem        ISSN： 0022-2623            Impact factor:   7.446


× No keyword cloud information.
  161 in total

1.  Hot spot analysis for driving the development of hits into leads in fragment-based drug discovery.

Authors:  David R Hall; Chi Ho Ngan; Brandon S Zerbe; Dima Kozakov; Sandor Vajda
Journal:  J Chem Inf Model       Date:  2011-12-15       Impact factor: 4.956

2.  Computational fragment-based screening using RosettaLigand: the SAMPL3 challenge.

Authors:  Ashutosh Kumar; Kam Y J Zhang
Journal:  J Comput Aided Mol Des       Date:  2012-01-15       Impact factor: 3.686

Review 3.  The influence of the 'organizational factor' on compound quality in drug discovery.

Authors:  Paul D Leeson; Stephen A St-Gallay
Journal:  Nat Rev Drug Discov       Date:  2011-09-30       Impact factor: 84.694

4.  Multiple ligand docking by Glide: implications for virtual second-site screening.

Authors:  Márton Vass; Ákos Tarcsay; György M Keserű
Journal:  J Comput Aided Mol Des       Date:  2012-05-26       Impact factor: 3.686

5.  Relationship between hot spot residues and ligand binding hot spots in protein-protein interfaces.

Authors:  Brandon S Zerbe; David R Hall; Sandor Vajda; Adrian Whitty; Dima Kozakov
Journal:  J Chem Inf Model       Date:  2012-07-24       Impact factor: 4.956

6.  Identifying chelators for metalloprotein inhibitors using a fragment-based approach.

Authors:  Jennifer A Jacobsen; Jessica L Fullagar; Melissa T Miller; Seth M Cohen
Journal:  J Med Chem       Date:  2010-12-28       Impact factor: 7.446

7.  Virtual screening using molecular simulations.

Authors:  Tianyi Yang; Johnny C Wu; Chunli Yan; Yuanfeng Wang; Ray Luo; Michael B Gonzales; Kevin N Dalby; Pengyu Ren
Journal:  Proteins       Date:  2011-04-12

8.  A Bioinorganic Approach to Fragment-Based Drug Discovery Targeting Metalloenzymes.

Authors:  Seth M Cohen
Journal:  Acc Chem Res       Date:  2017-07-17       Impact factor: 22.384

9.  Energetic analysis of fragment docking and application to structure-based pharmacophore hypothesis generation.

Authors:  Kathryn Loving; Noeris K Salam; Woody Sherman
Journal:  J Comput Aided Mol Des       Date:  2009-05-07       Impact factor: 3.686

10.  Chelator fragment libraries for targeting metalloproteinases.

Authors:  Arpita Agrawal; Sherida L Johnson; Jennifer A Jacobsen; Melissa T Miller; Li-Hsing Chen; Maurizio Pellecchia; Seth M Cohen
Journal:  ChemMedChem       Date:  2010-02-01       Impact factor: 3.466
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.