Literature DB >> 18455976

Xenohormesis: sensing the chemical cues of other species.

Konrad T Howitz1, David A Sinclair.   

Abstract

Many plant molecules interact with and modulate key regulators of mammalian physiology in ways that are beneficial to health, but why? We propose that heterotrophs (animals and fungi) are able to sense chemical cues synthesized by plants and other autotrophs in response to stress. These cues provide advance warning about deteriorating environmental conditions, allowing the heterotrophs to prepare for adversity while conditions are still favorable.

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Year:  2008        PMID: 18455976      PMCID: PMC2504011          DOI: 10.1016/j.cell.2008.04.019

Source DB:  PubMed          Journal:  Cell        ISSN: 0092-8674            Impact factor:   41.582


  21 in total

1.  Molecular understanding and modern application of traditional medicines: triumphs and trials.

Authors:  Timothy W Corson; Craig M Crews
Journal:  Cell       Date:  2007-09-07       Impact factor: 41.582

Review 2.  Unique properties of polyphenol stilbenes in the brain: more than direct antioxidant actions; gene/protein regulatory activity.

Authors:  Sylvain Doré
Journal:  Neurosignals       Date:  2005

Review 3.  Flavonoids as developmental regulators.

Authors:  Loverine P Taylor; Erich Grotewold
Journal:  Curr Opin Plant Biol       Date:  2005-06       Impact factor: 7.834

4.  Flavonoid evolution: an enzymic approach.

Authors:  H A Stafford
Journal:  Plant Physiol       Date:  1991-07       Impact factor: 8.340

Review 5.  A therapeutic role for sirtuins in diseases of aging?

Authors:  C H Westphal; M A Dipp; L Guarente
Journal:  Trends Biochem Sci       Date:  2007-11-05       Impact factor: 13.807

6.  Small molecule activators of sirtuins extend Saccharomyces cerevisiae lifespan.

Authors:  Konrad T Howitz; Kevin J Bitterman; Haim Y Cohen; Dudley W Lamming; Siva Lavu; Jason G Wood; Robert E Zipkin; Phuong Chung; Anne Kisielewski; Li-Li Zhang; Brandy Scherer; David A Sinclair
Journal:  Nature       Date:  2003-08-24       Impact factor: 49.962

7.  Arabidopsis sfd mutants affect plastidic lipid composition and suppress dwarfing, cell death, and the enhanced disease resistance phenotypes resulting from the deficiency of a fatty acid desaturase.

Authors:  Ashis Nandi; Kartikeya Krothapalli; Christen M Buseman; Maoyin Li; Ruth Welti; Alexander Enyedi; Jyoti Shah
Journal:  Plant Cell       Date:  2003-09-24       Impact factor: 11.277

Review 8.  Curcumin as "Curecumin": from kitchen to clinic.

Authors:  Ajay Goel; Ajaikumar B Kunnumakkara; Bharat B Aggarwal
Journal:  Biochem Pharmacol       Date:  2007-08-19       Impact factor: 5.858

9.  Human, rat, and mouse metabolism of resveratrol.

Authors:  Chongwoo Yu; Young Geun Shin; Anita Chow; Yongmei Li; Jerome W Kosmeder; Yong Sup Lee; Wendy H Hirschelman; John M Pezzuto; Rajendra G Mehta; Richard B van Breemen
Journal:  Pharm Res       Date:  2002-12       Impact factor: 4.200

10.  Sirtuin activators mimic caloric restriction and delay ageing in metazoans.

Authors:  Jason G Wood; Blanka Rogina; Siva Lavu; Konrad Howitz; Stephen L Helfand; Marc Tatar; David Sinclair
Journal:  Nature       Date:  2004-07-14       Impact factor: 69.504

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  84 in total

1.  Geopyxins A-E, ent-kaurane diterpenoids from endolichenic fungal strains Geopyxis aff. majalis and Geopyxis sp. AZ0066: structure-activity relationships of geopyxins and their analogues.

Authors:  E M Kithsiri Wijeratne; Bharat P Bashyal; Manping X Liu; Danilo D Rocha; G M Kamal B Gunaherath; Jana M U'Ren; Malkanthi K Gunatilaka; A Elizabeth Arnold; Luke Whitesell; A A Leslie Gunatilaka
Journal:  J Nat Prod       Date:  2012-01-20       Impact factor: 4.050

2.  Interspecies Chemical Signals Released into the Environment May Create Xenohormetic, Hormetic and Cytostatic Selective Forces that Drive the Ecosystemic Evolution of Longevity Regulation Mechanisms.

Authors:  Michelle T Burstein; Adam Beach; Vincent R Richard; Olivia Koupaki; Alejandra Gomez-Perez; Alexander A Goldberg; Pavlo Kyryakov; Simon D Bourque; Anastasia Glebov; Vladimir I Titorenko
Journal:  Dose Response       Date:  2011-07-27       Impact factor: 2.658

3.  President's address. Common mechanisms of multiple diseases: why vegetables and exercise are good for you.

Authors:  R Wayne Alexander
Journal:  Trans Am Clin Climatol Assoc       Date:  2010

Review 4.  Xenohormesis: health benefits from an eon of plant stress response evolution.

Authors:  Philip L Hooper; Paul L Hooper; Michael Tytell; Lászlo Vígh
Journal:  Cell Stress Chaperones       Date:  2010-06-04       Impact factor: 3.667

5.  Natural products and drug discovery. Can thousands of years of ancient medical knowledge lead us to new and powerful drug combinations in the fight against cancer and dementia?

Authors:  Hong-Fang Ji; Xue-Juan Li; Hong-Yu Zhang
Journal:  EMBO Rep       Date:  2009-02-20       Impact factor: 8.807

6.  Abiotic stresses induce different localizations of anthocyanins in Arabidopsis.

Authors:  Nik Kovinich; Gilbert Kayanja; Alexandra Chanoca; Marisa S Otegui; Erich Grotewold
Journal:  Plant Signal Behav       Date:  2015

7.  Molecular basis for efficacy of Guduchi and Madhuyashti feeding on different environmental stressors in Drosophila.

Authors:  Surabhi Singh; Madhu G Tapadia
Journal:  Cell Stress Chaperones       Date:  2019-03-27       Impact factor: 3.667

Review 8.  Deep learning approaches for natural product discovery from plant endophytic microbiomes.

Authors:  Shiva Abdollahi Aghdam; Amanda May Vivian Brown
Journal:  Environ Microbiome       Date:  2021-03-18

9.  Effect of heated naringenin on immunomodulatory properties and cellular antioxidant activity.

Authors:  Mouna Maatouk; Dorra Elgueder; Nadia Mustapha; Hind Chaaban; Imen Mokdad Bzéouich; Irina Loannou; Soumaya Kilani; Mohamed Ghoul; Kamel Ghedira; Leila Chekir-Ghedira
Journal:  Cell Stress Chaperones       Date:  2016-09-13       Impact factor: 3.667

10.  Inhibition of S6K by resveratrol: in search of the purpose.

Authors:  Mikhail V Blagosklonny
Journal:  Aging (Albany NY)       Date:  2009-06-29       Impact factor: 5.682

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