OBJECTIVE: The purpose of this study was to identify pregnancy-induced changes in biomechanical properties of the vaginal wall and to compare these with fibulin-5 knockout mice (Fbln5(-/-)) with and without prolapse. STUDY DESIGN: Mid-vaginal segments of nonpregnant and late-pregnant wild-type mice, Fbln5(-/-) with prolapse mice and Fbln5(-/-) mice without prolapse were studied. Tissue length at failure, maximal strain, maximal stress, and tissue stiffness were determined. RESULTS: Compared with nonpregnant mice, vaginas of pregnant and Fbln5(-/-) (with prolapse) mice exhibited decreased maximal stress, increased distensibility and strain, and decreased stiffness. Tissues from Fbln5(-/-) mice without prolapse were similar to nonpregnant wild-type animals. CONCLUSION: Pregnancy confers remarkable changes in the vaginal wall that include increased distensibility and decreased stiffness and maximal stress. Elastinopathy alone is insufficient to cause significant changes in these properties, but prolapse confers additional alterations in distensibility and stiffness that are similar to those changes that have been observed in pregnancy. These changes may contribute to the poor durability of many restorative surgical procedures for prolapse.
OBJECTIVE: The purpose of this study was to identify pregnancy-induced changes in biomechanical properties of the vaginal wall and to compare these with fibulin-5 knockout mice (Fbln5(-/-)) with and without prolapse. STUDY DESIGN: Mid-vaginal segments of nonpregnant and late-pregnant wild-type mice, Fbln5(-/-) with prolapse mice and Fbln5(-/-) mice without prolapse were studied. Tissue length at failure, maximal strain, maximal stress, and tissue stiffness were determined. RESULTS: Compared with nonpregnant mice, vaginas of pregnant and Fbln5(-/-) (with prolapse) mice exhibited decreased maximal stress, increased distensibility and strain, and decreased stiffness. Tissues from Fbln5(-/-) mice without prolapse were similar to nonpregnant wild-type animals. CONCLUSION: Pregnancy confers remarkable changes in the vaginal wall that include increased distensibility and decreased stiffness and maximal stress. Elastinopathy alone is insufficient to cause significant changes in these properties, but prolapse confers additional alterations in distensibility and stiffness that are similar to those changes that have been observed in pregnancy. These changes may contribute to the poor durability of many restorative surgical procedures for prolapse.
Authors: Muriel K Boreham; Clifford Y Wai; Rodney T Miller; Joseph I Schaffer; R Ann Word Journal: Am J Obstet Gynecol Date: 2002-07 Impact factor: 8.661
Authors: Muriel K Boreham; Clifford Y Wai; Rodney T Miller; Joseph I Schaffer; R Ann Word Journal: Am J Obstet Gynecol Date: 2002-12 Impact factor: 8.661
Authors: Jerry L Lowder; Kristen M Debes; Daniel K Moon; Nancy Howden; Steven D Abramowitch; Pamela A Moalli Journal: Obstet Gynecol Date: 2007-01 Impact factor: 7.661
Authors: Divya A Patel; Xiao Xu; Angela D Thomason; Scott B Ransom; Julie S Ivy; John O L DeLancey Journal: Am J Obstet Gynecol Date: 2006-03-30 Impact factor: 8.661
Authors: John O L DeLancey; Daniel M Morgan; Dee E Fenner; Rohna Kearney; Kenneth Guire; Janis M Miller; Hero Hussain; Wolfgang Umek; Yvonne Hsu; James A Ashton-Miller Journal: Obstet Gynecol Date: 2007-02 Impact factor: 7.661
Authors: Michel Cosson; Eric Lambaudie; Malik Boukerrou; Pierre Lobry; Gilles Crépin; Anne Ego Journal: Eur J Obstet Gynecol Reprod Biol Date: 2004-02-10 Impact factor: 2.435
Authors: Okechukwu A Ibeanu; Ralph R Chesson; Dane Sandquist; Javier Perez; Kerri Santiago; Thomas E Nolan Journal: Int Urogynecol J Date: 2010-03-24 Impact factor: 2.894
Authors: Keith T Downing; Mubashir Billah; Eva Raparia; Anup Shah; Moshe C Silverstein; Amanda Ahmad; Gregory S Boutis Journal: J Mech Behav Biomed Mater Date: 2013-09-08
Authors: Akinjide Akintunde; Kathryn M Robison; Daniel Capone; Laurephile Desrosiers; Leise R Knoepp; Kristin S Miller Journal: J Biomech Eng Date: 2018-11-15 Impact factor: 2.097
Authors: Daniel J Capone; Gabrielle L Clark; Derek Bivona; Benard O Ogola; Laurephile Desrosiers; Leise R Knoepp; Sarah H Lindsey; Kristin S Miller Journal: J Biomech Date: 2018-11-09 Impact factor: 2.712