OBJECTIVE: To correlate the live delivery rate with the initial level and rise of serum beta-hCG. DESIGN: Retrospective cohort analysis. SETTING: Large private academic center for assisted reproductive technologies and infertility. PATIENT(S): Records of all patients from 1999 to 2005 undergoing IVF with detectable early serum beta-hCG after ET. INTERVENTION(S): None. MAIN OUTCOME MEASURE(S): Live delivery rate. RESULT(S): Data from 6021 pregnancies were analyzed. Initial beta-hCG was predictive for delivery rate for all patients and for each age group. After controlling for the first beta-hCG, there were higher loss rates as age increased. Percent rise in second beta-hCG drawn 2 days later added predictive value. A decline in beta-hCG almost always resulted in a failure to deliver. There was a progressive increase in delivery rate as the percent rise in beta-hCG went from 0 to 100%; however, there was no further enhancement in delivery rates beyond the 100% rise point. While a better rise in beta-hCG was a good prognostic factor in all age groups, the differences in outcomes for the different age groups remained, even after controlling for first beta-hCG and percent rise. CONCLUSION(S): Initial level and rise in beta-hCG predicts live delivery rate, with oocyte age providing additional predictive value. The established logarithmic curves should provide convenient reference tools for tracking outcomes and counseling patients.
OBJECTIVE: To correlate the live delivery rate with the initial level and rise of serum beta-hCG. DESIGN: Retrospective cohort analysis. SETTING: Large private academic center for assisted reproductive technologies and infertility. PATIENT(S): Records of all patients from 1999 to 2005 undergoing IVF with detectable early serum beta-hCG after ET. INTERVENTION(S): None. MAIN OUTCOME MEASURE(S): Live delivery rate. RESULT(S): Data from 6021 pregnancies were analyzed. Initial beta-hCG was predictive for delivery rate for all patients and for each age group. After controlling for the first beta-hCG, there were higher loss rates as age increased. Percent rise in second beta-hCG drawn 2 days later added predictive value. A decline in beta-hCG almost always resulted in a failure to deliver. There was a progressive increase in delivery rate as the percent rise in beta-hCG went from 0 to 100%; however, there was no further enhancement in delivery rates beyond the 100% rise point. While a better rise in beta-hCG was a good prognostic factor in all age groups, the differences in outcomes for the different age groups remained, even after controlling for first beta-hCG and percent rise. CONCLUSION(S): Initial level and rise in beta-hCG predicts live delivery rate, with oocyte age providing additional predictive value. The established logarithmic curves should provide convenient reference tools for tracking outcomes and counseling patients.
Authors: Christopher B Morse; Kurt T Barnhart; Suneeta Senapati; Mary D Sammel; Erica C Prochaska; Anuja Dokras; Charalampos Chatzicharalampous; Christos Coutifaris Journal: Fertil Steril Date: 2016-01-23 Impact factor: 7.329
Authors: Kurt T Barnhart; Karl R Hansen; Mary D Stephenson; Rebecca Usadi; Anne Z Steiner; Marcelle I Cedars; Emily S Jungheim; Kathleen M Hoeger; Stephen A Krawetz; Benjie Mills; Meredith Alston; Christos Coutifaris; Suneeta Senapati; Sarita Sonalkar; Michael P Diamond; Robert A Wild; Mitchell Rosen; Mary D Sammel; Nanette Santoro; Esther Eisenberg; Hao Huang; Heping Zhang Journal: JAMA Date: 2021-08-03 Impact factor: 56.272