PURPOSE: We retrospectively examined a large cohort of females who underwent single blastocyst transfer to determine if initial β-human chorionic gonadotrophin (β-hCG) levels on day 7 after single vitrified-warmed blastocyst transfer (SVBT) could be used to predict pregnancy outcome. METHODS: The treatment cycles that gave rise to the early pregnancies included in this study were performed from 2004 to 2011 in a private infertility center. In SVBT cycles, embryos were transferred during a natural cycle or after endometrial preparation with exogenous estrogen and progesterone. A total of 11,458 cycles with β-hCG levels ≥1.0 UI/ml on day 7 after SVBT were evaluated. The proportion of live births per positive β-hCG cycle was established for 10 β-hCG ranges in 3 different age groups (Group A: 21-34 years old; Group B: 35-39 years old; Group C: 40-44 years old). RESULTS: The proportion of live births gradually increased from 1.5 to 93.7%, 0.8 to 87.9%, and 0.6 to 76.2% in Groups A, B, and C, respectively. For each range of β-hCG levels, the proportion of live births was higher for the younger age group, which reflected the increased risk of early pregnancy loss with advancing female age. CONCLUSIONS: β-hCG levels on day 7 after SVBT, in conjunction with maternal age, may be used to predict pregnancy outcomes.
PURPOSE: We retrospectively examined a large cohort of females who underwent single blastocyst transfer to determine if initial β-human chorionic gonadotrophin (β-hCG) levels on day 7 after single vitrified-warmed blastocyst transfer (SVBT) could be used to predict pregnancy outcome. METHODS: The treatment cycles that gave rise to the early pregnancies included in this study were performed from 2004 to 2011 in a private infertility center. In SVBT cycles, embryos were transferred during a natural cycle or after endometrial preparation with exogenous estrogen and progesterone. A total of 11,458 cycles with β-hCG levels ≥1.0 UI/ml on day 7 after SVBT were evaluated. The proportion of live births per positive β-hCG cycle was established for 10 β-hCG ranges in 3 different age groups (Group A: 21-34 years old; Group B: 35-39 years old; Group C: 40-44 years old). RESULTS: The proportion of live births gradually increased from 1.5 to 93.7%, 0.8 to 87.9%, and 0.6 to 76.2% in Groups A, B, and C, respectively. For each range of β-hCG levels, the proportion of live births was higher for the younger age group, which reflected the increased risk of early pregnancy loss with advancing female age. CONCLUSIONS: β-hCG levels on day 7 after SVBT, in conjunction with maternal age, may be used to predict pregnancy outcomes.
Authors: J Dor; E Rudak; S Rotmench; D Levran; J Blankstein; A Lusky; L Nebel; D M Serr; S Mashiach Journal: Hum Reprod Date: 1988-07 Impact factor: 6.918
Authors: János Urbancsek; Erik Hauzman; Péter Fedorcsák; Amrita Halmos; Nóra Dévényi; Zoltán Papp Journal: Fertil Steril Date: 2002-09 Impact factor: 7.329