OBJECTIVES: To examine the effect of season on biochemical markers of bone turnover in 51-to 75-year-old Irish women and to investigate whether such changes are related to vitamin D status. DESIGN: Longitudinal observational study. SETTING: Cork, Ireland (52 degrees N). SUBJECTS: 76 apparently healthy, free-living postmenopausal women (aged 51-75 years), not taking any medication and free from any condition likely to affect vitamin D status or calcium/bone metabolism. RESULTS: Serum 25-hydroxyvitamin D [S-25(OH)D] showed a clear seasonal variation with significantly higher (p < 0.001) values during late summer than late winter. Both urinary pyridinoline (Ur-Pyr) (p < 0.01) and deoxypyridinoline (Ur-Dpyr) (p < 0.001), but not serum parathyroid hormone or osteocalcin, showed a marked seasonal variation with lowest values during late-summer. Stratifying women into those with S-25(OH)D levels > or = or <50 nmol/L (vitamin D adequate and inadequate, respectively) during late-winter, showed that Ur-Pyr and Ur-Dpyr in both groups were significantly (p < 0.05) lower during late summer, and the magnitude of the reduction from winter to summer was similar in both groups. CONCLUSION: Seasonal changes in bone resorption markers appeared to be linked to seasonal changes in vitamin D status. Further research is needed to investigate the impact of these changes on risk of bone loss and fracture.
OBJECTIVES: To examine the effect of season on biochemical markers of bone turnover in 51-to 75-year-old Irish women and to investigate whether such changes are related to vitamin D status. DESIGN: Longitudinal observational study. SETTING: Cork, Ireland (52 degrees N). SUBJECTS: 76 apparently healthy, free-living postmenopausal women (aged 51-75 years), not taking any medication and free from any condition likely to affect vitamin D status or calcium/bone metabolism. RESULTS: Serum 25-hydroxyvitamin D [S-25(OH)D] showed a clear seasonal variation with significantly higher (p < 0.001) values during late summer than late winter. Both urinary pyridinoline (Ur-Pyr) (p < 0.01) and deoxypyridinoline (Ur-Dpyr) (p < 0.001), but not serum parathyroid hormone or osteocalcin, showed a marked seasonal variation with lowest values during late-summer. Stratifying women into those with S-25(OH)D levels > or = or <50 nmol/L (vitamin D adequate and inadequate, respectively) during late-winter, showed that Ur-Pyr and Ur-Dpyr in both groups were significantly (p < 0.05) lower during late summer, and the magnitude of the reduction from winter to summer was similar in both groups. CONCLUSION: Seasonal changes in bone resorption markers appeared to be linked to seasonal changes in vitamin D status. Further research is needed to investigate the impact of these changes on risk of bone loss and fracture.
Authors: A L Darling; K H Hart; H M Macdonald; K Horton; A R Kang'ombe; J L Berry; S A Lanham-New Journal: Osteoporos Int Date: 2012-04-14 Impact factor: 4.507
Authors: A Sebestyén; S Mester; Z Vokó; J Gajdácsi; P Cserháti; G Speer; B Patczai; V Warta; J Bódis; C Horváth; I Boncz Journal: Osteoporos Int Date: 2014-12-04 Impact factor: 4.507
Authors: Philippe Vuistiner; Valentin Rousson; Hugues Henry; Pierre Lescuyer; Olivier Boulat; Jean-Michel Gaspoz; Vincent Mooser; Peter Vollenweider; Gerard Waeber; Jacques Cornuz; Fred Paccaud; Murielle Bochud; Idris Guessous Journal: Biomed Res Int Date: 2015-09-01 Impact factor: 3.411
Authors: Alexandra Mavroeidi; Lorna Aucott; Alison J Black; William D Fraser; David M Reid; Helen M Macdonald Journal: PLoS One Date: 2013-01-08 Impact factor: 3.240