| Literature DB >> 184494 |
Abstract
The effects of prostaglandins on human monocyte chemotaxis were studied in vitro. None of the prostaglandins tested, including members of the A, B, E or F series, were chemotactic for monocytes. Prostaglandin E2 however, enhanced the chemotactic responsiveness of monocytes to complement - activated human serum by almost 200%. The enhancement of chemotaxis was not directly related to the ability of PGE2 to raise intracellular cyclic AMP levels. These studies support a role for prostaglandins as modulators of the inflammatory response.Entities:
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Year: 1976 PMID： 184494 DOI： 10.1016/0090-6980(76)90022-8
Source DB: PubMed Journal: Prostaglandins ISSN： 0090-6980