Restoration by ketoprofen of defective neutrophil granulocyte migration induced in guinea-pigs by plasma from cancer patients.

The infiltration by inflammatory cells of dacron mesh tissue containing live BCG, implanted under the skin of male and female guinea-pigs treated with normal control and cancer patients' plasmas, was investigated. These cells migrated from the blood vessels to the peri-implant region under the influence of local chemotactic mechanisms generated by the bacilli. Animals given normal or cancer patients' plasmas were unable to produce normal levels of cellular infiltration. This was more markedly reduced with plasma from patients with malignant disease. Cell counts in treated animals have shown significant reduction in while-cell counts but the more marked effect was seen on the polymorphonuclear neutrophil level. Ketoprofen restored normal infiltration responses to animals simultaneously given plasma from cancer patients. These observations further underline the importance of prostaglandins in both inflammation and malignant disease.