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Literature DB >> 18449360

Neutrophil gelatinase-associated lipocalin: new paths for an old shuttle.

Abstract

Neutrophil Gelatinase-Associated Lipocalin (NGAL) is a lipocalin that is well known for its functions as a shuttle for iron and siderophores, which comprises a critical component of innate immunity to exogenous bacterial infections. However, several lines of recent evidence have added new dimensions of functionality that have attracted the interest of cancer biologists and oncologists. This review will highlight the exciting new paths and roles that are emerging for NGAL in human cancers, in the tissue response to anticancer therapy, and in the acute kidney injuries that commonly complicate the care of patients with cancer. The evidence for NGAL induction and its role in various human cancers will be explored. The current status of NGAL as a predictive non-invasive biomarker of acute kidney injuries will also be examined.

Entities: Chemical Disease Gene Species

Year: 2007 PMID： 18449360 PMCID： PMC2361391

Source DB: PubMed Journal: Cancer Ther

64 in total

1. Neutrophil gelatinase-associated lipocalin (NGAL) as a biomarker for acute renal injury after cardiac surgery.

Authors: Jaya Mishra; Catherine Dent; Ridwan Tarabishi; Mark M Mitsnefes; Qing Ma; Caitlin Kelly; Stacey M Ruff; Kamyar Zahedi; Mingyuan Shao; Judy Bean; Kiyoshi Mori; Jonathan Barasch; Prasad Devarajan
Journal: Lancet Date: 2005 Apr 2-8 Impact factor: 79.321

2. Proteomics-based validation of genomic data: applications in colorectal cancer diagnosis.

Authors: Juan Madoz-Gúrpide; Paula López-Serra; Jorge Luis Martínez-Torrecuadrada; Lydia Sánchez; Luis Lombardía; J Ignacio Casal
Journal: Mol Cell Proteomics Date: 2006-05-29 Impact factor: 5.911

3. Ligand preference inferred from the structure of neutrophil gelatinase associated lipocalin.

Authors: D H Goetz; S T Willie; R S Armen; T Bratt; N Borregaard; R K Strong
Journal: Biochemistry Date: 2000-02-29 Impact factor: 3.162

4. Characterization of gene expression profiles in intraductal papillary-mucinous tumors of the pancreas.

Authors: Benoit Terris; Ekaterina Blaveri; Tatjana Crnogorac-Jurcevic; Melanie Jones; Edoardo Missiaglia; Philippe Ruszniewski; Alain Sauvanet; Nicholas R Lemoine
Journal: Am J Pathol Date: 2002-05 Impact factor: 4.307

Review 5. Lipocalins and cancer.

Authors: T Bratt
Journal: Biochim Biophys Acta Date: 2000-10-18

6. An iron delivery pathway mediated by a lipocalin.

Authors: Jun Yang; David Goetz; Jau Yi Li; Wenge Wang; Kiyoshi Mori; Daria Setlik; Tonggong Du; Hediye Erdjument-Bromage; Paul Tempst; Roland Strong; Jonathan Barasch
Journal: Mol Cell Date: 2002-11 Impact factor: 17.970

7. Neutrophil gelatinase-associated lipocalin in normal and neoplastic human tissues. Cell type-specific pattern of expression.

Authors: A Friedl; S P Stoesz; P Buckley; M N Gould
Journal: Histochem J Date: 1999-07

8. Overexpression of neu-related lipocalin (NRL) in neu-initiated but not ras or chemically initiated rat mammary carcinomas.

Authors: S P Stoesz; M N Gould
Journal: Oncogene Date: 1995-12-07 Impact factor: 9.867

Review 9. Enterobactin: an archetype for microbial iron transport.

Authors: Kenneth N Raymond; Emily A Dertz; Sanggoo S Kim
Journal: Proc Natl Acad Sci U S A Date: 2003-03-24 Impact factor: 11.205

10. Processing of VEGF-A by matrix metalloproteinases regulates bioavailability and vascular patterning in tumors.

Authors: Sunyoung Lee; Shahla M Jilani; Ganka V Nikolova; Darren Carpizo; M Luisa Iruela-Arispe
Journal: J Cell Biol Date: 2005-05-23 Impact factor: 10.539

25 in total

1. Lipocalin 2 is essential for chronic kidney disease progression in mice and humans.

Authors: Amandine Viau; Khalil El Karoui; Denise Laouari; Martine Burtin; Clément Nguyen; Kiyoshi Mori; Evangéline Pillebout; Thorsten Berger; Tak Wah Mak; Bertrand Knebelmann; Gérard Friedlander; Jonathan Barasch; Fabiola Terzi
Journal: J Clin Invest Date: 2010-11 Impact factor: 14.808

Neutrophil gelatinase-associated lipocalin: new paths for an old shuttle.

1. Neutrophil gelatinase-associated lipocalin (NGAL) as a biomarker for acute renal injury after cardiac surgery.

2. Proteomics-based validation of genomic data: applications in colorectal cancer diagnosis.

3. Ligand preference inferred from the structure of neutrophil gelatinase associated lipocalin.

4. Characterization of gene expression profiles in intraductal papillary-mucinous tumors of the pancreas.

Review 5. Lipocalins and cancer.

6. An iron delivery pathway mediated by a lipocalin.

7. Neutrophil gelatinase-associated lipocalin in normal and neoplastic human tissues. Cell type-specific pattern of expression.

8. Overexpression of neu-related lipocalin (NRL) in neu-initiated but not ras or chemically initiated rat mammary carcinomas.

Review 9. Enterobactin: an archetype for microbial iron transport.

10. Processing of VEGF-A by matrix metalloproteinases regulates bioavailability and vascular patterning in tumors.

1. Lipocalin 2 is essential for chronic kidney disease progression in mice and humans.

Review 2. The use of targeted biomarkers for chronic kidney disease.

Review 3. Neutrophil gelatinase-associated lipocalin--an emerging troponin for kidney injury.

4. Reactive astrocytes secrete lcn2 to promote neuron death.

Review 5. Measurement of renal function in patients with chronic kidney disease.

6. Kidney safety during surgical pneumoperitoneum: an experimental study in rats.

Review 7. Neutrophil gelatinase-associated lipocalin: a promising biomarker for human acute kidney injury.

8. Emerging urinary biomarkers in the diagnosis of acute kidney injury.

9. The Ligands of Neutrophil Gelatinase-Associated Lipocalin.

Review 10. The future of pediatric acute kidney injury management--biomarkers.