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Literature DB >> 18790370

The future of pediatric acute kidney injury management--biomarkers.

Abstract

Acute kidney injury (AKI) represents a common and devastating problem in clinical medicine. A major reason is the lack of early biomarkers for AKI, and hence an unacceptable delay in initiating therapy. Fortunately, the application of innovative technologies has uncovered several novel biomarkers. The most promising of these are included in a putative AKI biomarker panel, consisting of neutrophil gelatinase-associated lipocalin, interleukin-18, and kidney injury molecule-1. These biomarkers have completed initial validation, and have entered the prospective screening stage in the biomarker development process, facilitated by the development of commercial tools for their reproducible measurement across laboratories. The availability of a panel of validated biomarkers will revolutionize renal and critical care, and enable the practice of personalized and predictive medicine at an unprecedented level.

Entities: Chemical Disease Gene Species

Mesh：

Substances：
Biomarkers

Year: 2008 PMID： 18790370 PMCID： PMC2597020 DOI： 10.1016/j.semnephrol.2008.05.010

Source DB: PubMed Journal: Semin Nephrol ISSN： 0270-9295 Impact factor: 5.299

37 in total

1. Neutrophil gelatinase-associated lipocalin (NGAL) as a biomarker for acute renal injury after cardiac surgery.

Authors: Jaya Mishra; Catherine Dent; Ridwan Tarabishi; Mark M Mitsnefes; Qing Ma; Caitlin Kelly; Stacey M Ruff; Kamyar Zahedi; Mingyuan Shao; Judy Bean; Kiyoshi Mori; Jonathan Barasch; Prasad Devarajan
Journal: Lancet Date: 2005 Apr 2-8 Impact factor: 79.321

2. Kidney injury molecule-1 (KIM-1), a putative epithelial cell adhesion molecule containing a novel immunoglobulin domain, is up-regulated in renal cells after injury.

Authors: T Ichimura; J V Bonventre; V Bailly; H Wei; C A Hession; R L Cate; M Sanicola
Journal: J Biol Chem Date: 1998-02-13 Impact factor: 5.157

3. Acute kidney injury, mortality, length of stay, and costs in hospitalized patients.

Authors: Glenn M Chertow; Elisabeth Burdick; Melissa Honour; Joseph V Bonventre; David W Bates
Journal: J Am Soc Nephrol Date: 2005-09-21 Impact factor: 10.121

4. Urine NGAL predicts severity of acute kidney injury after cardiac surgery: a prospective study.

Authors: Michael Bennett; Catherine L Dent; Qing Ma; Sudha Dastrala; Frank Grenier; Ryan Workman; Hina Syed; Salman Ali; Jonathan Barasch; Prasad Devarajan
Journal: Clin J Am Soc Nephrol Date: 2008-03-12 Impact factor: 8.237

Review 5. The role of interleukin-18 in renal injury.

Authors: Jeffrey A Leslie; Kirstan K Meldrum
Journal: J Surg Res Date: 2007-07-23 Impact factor: 2.192

6. Kidney Injury Molecule-1 (KIM-1): a novel biomarker for human renal proximal tubule injury.

Authors: Won K Han; Veronique Bailly; Rekha Abichandani; Ravi Thadhani; Joseph V Bonventre
Journal: Kidney Int Date: 2002-07 Impact factor: 10.612

7. Comparison of kidney injury molecule-1 and other nephrotoxicity biomarkers in urine and kidney following acute exposure to gentamicin, mercury, and chromium.

Authors: Yuzhao Zhou; Vishal S Vaidya; Ronald P Brown; Jun Zhang; Barry A Rosenzweig; Karol L Thompson; Terry J Miller; Joseph V Bonventre; Peter L Goering
Journal: Toxicol Sci Date: 2007-10-13 Impact factor: 4.849

8. Urinary interleukin-18 is a marker of human acute tubular necrosis.

Authors: Chirag R Parikh; Alkesh Jani; Vyacheslav Y Melnikov; Sarah Faubel; Charles L Edelstein
Journal: Am J Kidney Dis Date: 2004-03 Impact factor: 8.860

9. Plasma neutrophil gelatinase-associated lipocalin predicts acute kidney injury, morbidity and mortality after pediatric cardiac surgery: a prospective uncontrolled cohort study.

Authors: Catherine L Dent; Qing Ma; Sudha Dastrala; Michael Bennett; Mark M Mitsnefes; Jonathan Barasch; Prasad Devarajan
Journal: Crit Care Date: 2007 Impact factor: 9.097

Review 10. Biomarkers for the early detection of acute kidney injury.

Authors: Mai T Nguyen; Prasad Devarajan
Journal: Pediatr Nephrol Date: 2007-03-30 Impact factor: 3.714

7 in total

Review 1. Acute kidney injury: can we improve prognosis?

Authors: Christine W Hsu; Jordan M Symons
Journal: Pediatr Nephrol Date: 2010-04-09 Impact factor: 3.714

2. Combining functional and tubular damage biomarkers improves diagnostic precision for acute kidney injury after cardiac surgery.

Authors: Rajit K Basu; Hector R Wong; Catherine D Krawczeski; Derek S Wheeler; Peter B Manning; Lakhmir S Chawla; Prasad Devarajan; Stuart L Goldstein
Journal: J Am Coll Cardiol Date: 2014-12-30 Impact factor: 24.094