BACKGROUND: Major depressive disorder is estimated to occur in 10%-25% of people with cancer, and it has been inconsistently linked to increased mortality. OBJECTIVE: This pilot study investigates the association of depression and survival in advanced non-small cell lung cancer (NSCLC) patients. METHOD: Forty-three recently-diagnosed advanced NSCLC patients completed the Hospital Anxiety and Depression Scale and were followed prospectively. RESULTS: Patients with depression had poorer survival. Median survival was four times shorter than those without depression. Controlling for baseline performance status, depression predicted 6-month mortality, but was not significant for overall survival. CONCLUSION: Although depression after advanced-NSCLC diagnosis was associated with poorer survival at 6 months, this association was not present for overall survival; however, further research with larger samples should be pursued.
BACKGROUND: Major depressive disorder is estimated to occur in 10%-25% of people with cancer, and it has been inconsistently linked to increased mortality. OBJECTIVE: This pilot study investigates the association of depression and survival in advanced non-small cell lung cancer (NSCLC) patients. METHOD: Forty-three recently-diagnosed advanced NSCLCpatients completed the Hospital Anxiety and Depression Scale and were followed prospectively. RESULTS:Patients with depression had poorer survival. Median survival was four times shorter than those without depression. Controlling for baseline performance status, depression predicted 6-month mortality, but was not significant for overall survival. CONCLUSION: Although depression after advanced-NSCLC diagnosis was associated with poorer survival at 6 months, this association was not present for overall survival; however, further research with larger samples should be pursued.
Authors: Kathryn Elizabeth Hudson; Steven Paul Wolf; Gregory P Samsa; Arif H Kamal; Amy Pickar Abernethy; Thomas William LeBlanc Journal: J Palliat Med Date: 2018-02-08 Impact factor: 2.947
Authors: William F Pirl; Joseph A Greer; Lara Traeger; Vicki Jackson; Inga T Lennes; Emily R Gallagher; Pedro Perez-Cruz; Rebecca S Heist; Jennifer S Temel Journal: J Clin Oncol Date: 2012-03-19 Impact factor: 44.544
Authors: Charles B Simone; Joseph S Friedberg; Eli Glatstein; James P Stevenson; Daniel H Sterman; Stephen M Hahn; Keith A Cengel Journal: J Thorac Dis Date: 2012-02 Impact factor: 2.895
Authors: William F Pirl; Lara Traeger; Joseph A Greer; Heather Bemis; Emily Gallagher; Inga Lennes; Lecia Sequist; Rebecca Heist; Jennifer S Temel Journal: Oncologist Date: 2011-08-01