BACKGROUND: Approximately two-thirds of patients with depression experience physical pain symptoms. Coexisting pain complicates the treatment of depression and is associated with worse depression outcomes. OBJECTIVE: The authors reviewed the effect of newer antidepressants on pain in patients with depression. METHOD: The authors searched systematically for trials of second-generation antidepressants that enrolled depression patients and reported pain outcomes, pooling changes on the pain visual-analog scale (VAS), using random-effects models. RESULTS: Eight trials were eligible. Pooled analysis of head-to-head trials showed no difference in VAS between duloxetine and paroxetine. Both drugs were superior to placebo. CONCLUSION: The authors found insufficient evidence to support the choice of one second-generation antidepressant over another in patients with pain accompanying depression.
BACKGROUND: Approximately two-thirds of patients with depression experience physical pain symptoms. Coexisting pain complicates the treatment of depression and is associated with worse depression outcomes. OBJECTIVE: The authors reviewed the effect of newer antidepressants on pain in patients with depression. METHOD: The authors searched systematically for trials of second-generation antidepressants that enrolled depressionpatients and reported pain outcomes, pooling changes on the pain visual-analog scale (VAS), using random-effects models. RESULTS: Eight trials were eligible. Pooled analysis of head-to-head trials showed no difference in VAS between duloxetine and paroxetine. Both drugs were superior to placebo. CONCLUSION: The authors found insufficient evidence to support the choice of one second-generation antidepressant over another in patients with pain accompanying depression.
Authors: Susan G Ball; Durisala Desaiah; Melissa E Spann; Qi Zhang; James M Russell; Michael J Robinson; Koen Demyttenaere Journal: Prim Care Companion CNS Disord Date: 2011
Authors: Kurt Kroenke; Matthew J Bair; Teresa M Damush; Jingwei Wu; Shawn Hoke; Jason Sutherland; Wanzhu Tu Journal: JAMA Date: 2009-05-27 Impact factor: 56.272
Authors: Carsten Leue; Servaas Buijs; Jacqueline Strik; Richel Lousberg; Jasper Smit; Maarten van Kleef; Jim van Os Journal: BMJ Open Date: 2012-07-19 Impact factor: 2.692