Literature DB >> 18447506

The Alzheimer's beta amyloid (Abeta1-39) monomer in an implicit solvent.

Priya Anand1, F S Nandel, Ulrich H E Hansmann.   

Abstract

Results from replica-exchange and regular room temperature molecular dynamics simulations of the Alzheimer's beta amyloid (Abeta(1-39)) monomer in an implicit solvent are reported. Our data indicate that at room temperature, the monomer assumes random-coil and soluble conformations. No beta content is observed which therefore seems to be a product of oligomerization and aggregation of monomers.

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Year:  2008        PMID： 18447506      PMCID： PMC5947597          DOI： 10.1063/1.2907718

Source DB:  PubMed          Journal:  J Chem Phys        ISSN： 0021-9606            Impact factor:   3.488


  26 in total

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8.  The Alzheimer beta-amyloid (Abeta(1-39)) dimer in an implicit solvent.

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9.  Structural diversity of Alzheimer's disease amyloid-β dimers and their role in oligomerization and fibril formation.

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