BACKGROUND: The aim was to describe pre- and perinatal data and long-term neurodevelopmental outcome (15-19 years) in children born at term with Apgar score <7 at 5 min and moderate neonatal encephalopathy. METHODS: The study is based on a population-based birth-cohort of children born in Sweden in 1985. Maternal, delivery, neonatal, and neuropaediatric data were compiled. Neurodevelopmental status was classified according to the presence of 1. cerebral palsy or other major impairments, 2. exclusively cognitive impairments, and 3. no impairments. RESULTS: The majority of the children (81%) had cognitive dysfunctions, with or without other impairments, such as cerebral palsy. The rates of post-term birth (19% versus 8%) and breech presentation (12% versus 3%) were significantly higher than in the general Swedish population. Pre- and perinatal data did not differ notably between the three outcome groups. Questionable or suboptimal obstetric care was common (55%). CONCLUSIONS: The study shows that children born at term with moderate neonatal encephalopathy have a high rate of cognitive dysfunctions with or without cerebral palsy at long-term follow-up. Our pre- and perinatal data did not correlate with outcome.
BACKGROUND: The aim was to describe pre- and perinatal data and long-term neurodevelopmental outcome (15-19 years) in children born at term with Apgar score <7 at 5 min and moderate neonatal encephalopathy. METHODS: The study is based on a population-based birth-cohort of children born in Sweden in 1985. Maternal, delivery, neonatal, and neuropaediatric data were compiled. Neurodevelopmental status was classified according to the presence of 1. cerebral palsy or other major impairments, 2. exclusively cognitive impairments, and 3. no impairments. RESULTS: The majority of the children (81%) had cognitive dysfunctions, with or without other impairments, such as cerebral palsy. The rates of post-term birth (19% versus 8%) and breech presentation (12% versus 3%) were significantly higher than in the general Swedish population. Pre- and perinatal data did not differ notably between the three outcome groups. Questionable or suboptimal obstetric care was common (55%). CONCLUSIONS: The study shows that children born at term with moderate neonatal encephalopathy have a high rate of cognitive dysfunctions with or without cerebral palsy at long-term follow-up. Our pre- and perinatal data did not correlate with outcome.
Authors: Anne C C Lee; Luke C Mullany; James M Tielsch; Joanne Katz; Subarna K Khatry; Steven C LeClerq; Ramesh K Adhikari; Gary L Darmstadt Journal: Pediatrics Date: 2011-09-26 Impact factor: 7.124
Authors: Anne C C Lee; Naoko Kozuki; Hannah Blencowe; Theo Vos; Adil Bahalim; Gary L Darmstadt; Susan Niermeyer; Matthew Ellis; Nicola J Robertson; Simon Cousens; Joy E Lawn Journal: Pediatr Res Date: 2013-12 Impact factor: 3.756
Authors: Mohamed M Helmy; Eva Ruusuvuori; Paul V Watkins; Juha Voipio; Patrick O Kanold; Kai Kaila Journal: Brain Date: 2012-11-03 Impact factor: 13.501
Authors: Lauren C Weeke; Floris Groenendaal; Kalyani Mudigonda; Mats Blennow; Maarten H Lequin; Linda C Meiners; Ingrid C van Haastert; Manon J Benders; Boubou Hallberg; Linda S de Vries Journal: J Pediatr Date: 2018-01 Impact factor: 4.406