| Literature DB >> 18443594 |
Kathrin Saar, Alfred Beck, Marie-Thérèse Bihoreau, Ewan Birney, Denise Brocklebank, Yuan Chen, Edwin Cuppen, Stephanie Demonchy, Joaquin Dopazo, Paul Flicek, Mario Foglio, Asao Fujiyama, Ivo G Gut, Dominique Gauguier, Roderic Guigo, Victor Guryev, Matthias Heinig, Oliver Hummel, Niels Jahn, Sven Klages, Vladimir Kren, Michael Kube, Heiner Kuhl, Takashi Kuramoto, Yoko Kuroki, Doris Lechner, Young-Ae Lee, Nuria Lopez-Bigas, G Mark Lathrop, Tomoji Mashimo, Ignacio Medina, Richard Mott, Giannino Patone, Jeanne-Antide Perrier-Cornet, Matthias Platzer, Michal Pravenec, Richard Reinhardt, Yoshiyuki Sakaki, Markus Schilhabel, Herbert Schulz, Tadao Serikawa, Medya Shikhagaie, Shouji Tatsumoto, Stefan Taudien, Atsushi Toyoda, Birger Voigt, Diana Zelenika, Heike Zimdahl, Norbert Hubner.
Abstract
The laboratory rat is one of the most extensively studied model organisms. Inbred laboratory rat strains originated from limited Rattus norvegicus founder populations, and the inherited genetic variation provides an excellent resource for the correlation of genotype to phenotype. Here, we report a survey of genetic variation based on almost 3 million newly identified SNPs. We obtained accurate and complete genotypes for a subset of 20,238 SNPs across 167 distinct inbred rat strains, two rat recombinant inbred panels and an F2 intercross. Using 81% of these SNPs, we constructed high-density genetic maps, creating a large dataset of fully characterized SNPs for disease gene mapping. Our data characterize the population structure and illustrate the degree of linkage disequilibrium. We provide a detailed SNP map and demonstrate its utility for mapping of quantitative trait loci. This community resource is openly available and augments the genetic tools for this workhorse of physiological studies.Entities:
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Year: 2008 PMID： 18443594 PMCID： PMC5915293 DOI： 10.1038/ng.124
Source DB: PubMed Journal: Nat Genet ISSN： 1061-4036 Impact factor: 38.330