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Literature DB >> 18443013

Studying gene function in Caenorhabditis elegans using RNA-mediated interference.

Abstract

The RNA interference (RNAi) method for targeted gene silencing is widely used in Caenorhabditis elegans for large-scale functional genomic studies, analysis of limited gene sets and detailed analysis of individual gene function. The application of RNAi has identified genes that participate in various aspects of development, physiology and cell biology. In addition, RNAi has been used to identify interacting genes and to study functionally redundant genes. This review discusses the various applications of RNAi in C. elegans, focusing particularly on the analysis of developmental processes.

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Year: 2008 PMID： 18443013 DOI： 10.1093/bfgp/eln019

Source DB: PubMed Journal: Brief Funct Genomic Proteomic ISSN： 1473-9550

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Cited

7 in total

Studying gene function in Caenorhabditis elegans using RNA-mediated interference.

Review 1. Insights to transcriptional networks by using high throughput RNAi strategies.

2. Using C. elegans to identify the protease targets of serpins in vivo.

Review 3. Functional toxicogenomics: mechanism-centered toxicology.

4. An anoxia-starvation model for ischemia/reperfusion in C. elegans.

5. C. elegans rrf-1 mutations maintain RNAi efficiency in the soma in addition to the germline.

6. Functional analysis of the cathepsin-like cysteine protease genes in adult Brugia malayi using RNA interference.

7. Testis-specific Fank1 gene in knockdown mice produces oligospermia via apoptosis.