Literature DB >> 18442907

Synthesis of 2-[3-(7-Chloro-quinolin-4-ylamino)-alkyl]-1-(substituted phenyl)-2,3,4,9-tetrahydro-1H-beta-carbolines as a new class of antimalarial agents.

Leena Gupta1, Kumkum Srivastava, Shubhra Singh, S K Puri, Prem M S Chauhan.   

Abstract

A series of hybrid molecules 2-[3-(7-Chloro-quinolin-4-ylamino)-alkyl]-1-(substituted phenyl)-2,3,4,9-tetrahydro-1H-beta-carbolines have been synthesized and screened for their in vitro antimalarial activity against chloroquine-sensitive strains of Plasmodium falciparum. Compounds 26, 32, and 34 have shown MIC in the range of 0.05-0.11 microM and are in vitro several folds more active than chloroquine.

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Year:  2008        PMID： 18442907     DOI： 10.1016/j.bmcl.2008.04.030

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  10 in total

1.  Probing the B- & C-rings of the antimalarial tetrahydro-β-carboline MMV008138 for steric and conformational constraints.

Authors:  Sha Ding; Maryam Ghavami; Joshua H Butler; Emilio F Merino; Carla Slebodnick; Maria B Cassera; Paul R Carlier
Journal:  Bioorg Med Chem Lett       Date:  2020-09-06       Impact factor: 2.823

2.  Structure-based design of novel small-molecule inhibitors of Plasmodium falciparum.

Authors:  Sandhya Kortagere; William J Welsh; Joanne M Morrisey; Thomas Daly; Ijeoma Ejigiri; Photini Sinnis; Akhil B Vaidya; Lawrence W Bergman
Journal:  J Chem Inf Model       Date:  2010-05-24       Impact factor: 4.956

3.  Design, synthesis, and biological evaluation of callophycin A and analogues as potential chemopreventive and anticancer agents.

Authors:  Li Shen; Eun-Jung Park; Tamara P Kondratyuk; Daniela Guendisch; Laura Marler; John M Pezzuto; Anthony D Wright; Dianqing Sun
Journal:  Bioorg Med Chem       Date:  2011-09-16       Impact factor: 3.641

4.  Traceless synthesis of diketopiperazine fused tetrahydro-β-carbolines on soluble polymer support.

Authors:  Kaushik Chanda; Cheng-Ting Chou; Jin-Ji Lai; Shu-Fen Lin; Gorakh S Yellol; Chung-Ming Sun
Journal:  Mol Divers       Date:  2010-10-10       Impact factor: 2.943

5.  Structural modifications of quinoline-based antimalarial agents: Recent developments.

Authors:  Sandhya Bawa; Suresh Kumar; Sushma Drabu; Rajiv Kumar
Journal:  J Pharm Bioallied Sci       Date:  2010-04

Review 6.  Two decades of recent advances of Ugi reactions: synthetic and pharmaceutical applications.

Authors:  Manar Ahmed Fouad; Hamida Abdel-Hamid; Mohammed Salah Ayoup
Journal:  RSC Adv       Date:  2020-11-23       Impact factor: 4.036

7.  Synthesis and Evaluation of Antiplasmodial Efficacy of β-Carboline Derivatives against Murine Malaria.

Authors:  Varun Gorki; Rahul Singh; Neha Sylvia Walter; Upma Bagai; Deepak B Salunke
Journal:  ACS Omega       Date:  2018-10-15

Review 8.  β-Carboline-based molecular hybrids as anticancer agents: a brief sketch.

Authors:  Jay Prakash Soni; Yogesh Yeole; Nagula Shankaraiah
Journal:  RSC Med Chem       Date:  2021-03-24

9.  The diketopiperazine-fused tetrahydro-β-carboline scaffold as a model peptidomimetic with an unusual α-turn secondary structure.

Authors:  Francesco Airaghi; Andrea Fiorati; Giordano Lesma; Manuele Musolino; Alessandro Sacchetti; Alessandra Silvani
Journal:  Beilstein J Org Chem       Date:  2013-01-22       Impact factor: 2.883

10.  Novel Polycondensed Partly Saturated β-Carbolines Including Ferrocene Derivatives: Synthesis, DFT-Supported Structural Analysis, Mechanism of Some Diastereoselective Transformations and a Preliminary Study of Their in vitro Antiproliferative Effects.

Authors:  Kinga Judit Fodor; Dániel Hutai; Tamás Jernei; Angéla Takács; Zsófia Szász; Máté Sulyok-Eiler; Veronika Harmat; Rita Oláh Szabó; Gitta Schlosser; Ferenc Hudecz; László Kőhidai; Antal Csámpai
Journal:  Molecules       Date:  2020-03-31       Impact factor: 4.411
  10 in total

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