| Literature DB >> 18442481 |
Johanna Weigert1, Markus Neumeier, Josef Wanninger, Sylvia Wurm, Andrea Kopp, Franziska Schober, Michael Filarsky, Andreas Schäffler, Martina Zeitoun, Charalampos Aslanidis, Christa Buechler.
Abstract
The abundance of the adiponectin receptors, AdipoR1 and AdipoR2, and the effects of the antidiabetic adipokine adiponectin in monocytes of normal-weight and overweight controls and type 2 diabetic patients (T2D) were analyzed. AdipoR1 and AdipoR2 mRNAs were increased in monocytes of obese controls and T2D patients when compared to normal-weight controls, and AdipoR1 mRNA positively correlated to AdipoR2 mRNA, the waist to hip ratio and systemic adiponectin. However, AdipoR1 and AdipoR2 proteins were lower in monocytes of T2D compared to normal-weight donors. Induction of IL-6 and IL-8 by adiponectin, an effect involving p38 MAPK, was also reduced in T2D monocytes.Entities:
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Year: 2008 PMID： 18442481 DOI： 10.1016/j.febslet.2008.04.031
Source DB: PubMed Journal: FEBS Lett ISSN： 0014-5793 Impact factor: 4.124