Literature DB >> 18441001

gpDB: a database of GPCRs, G-proteins, effectors and their interactions.

Margarita C Theodoropoulou1, Pantelis G Bagos, Ioannis C Spyropoulos, Stavros J Hamodrakas.   

Abstract

UNLABELLED: gpDB is a publicly accessible, relational database, containing information about G-proteins, G-protein coupled receptors (GPCRs) and effectors, as well as information concerning known interactions between these molecules. The sequences are classified according to a hierarchy of different classes, families and subfamilies based on literature search. The main innovation besides the classification of G-proteins, GPCRs and effectors is the relational model of the database, describing the known coupling specificity of GPCRs to their respective alpha subunits of G-proteins, and also the specific interaction between G-proteins and their effectors, a unique feature not available in any other database. AVAILABILITY: http://bioinformatics.biol.uoa.gr/gpDB CONTACT: shamodr@biol.uoa.gr SUPPLEMENTARY INFORMATION: Supplementary data are available at Bioinformatics online.

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Year:  2008        PMID: 18441001     DOI: 10.1093/bioinformatics/btn206

Source DB:  PubMed          Journal:  Bioinformatics        ISSN: 1367-4803            Impact factor:   6.937


  10 in total

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Journal:  Br J Pharmacol       Date:  2010-12       Impact factor: 8.739

2.  GPCR-OKB: the G Protein Coupled Receptor Oligomer Knowledge Base.

Authors:  George Khelashvili; Kevin Dorff; Jufang Shan; Marta Camacho-Artacho; Lucy Skrabanek; Bas Vroling; Michel Bouvier; Lakshmi A Devi; Susan R George; Jonathan A Javitch; Martin J Lohse; Graeme Milligan; Richard R Neubig; Krzysztof Palczewski; Marc Parmentier; Jean-Philippe Pin; Gerrit Vriend; Fabien Campagne; Marta Filizola
Journal:  Bioinformatics       Date:  2010-05-25       Impact factor: 6.937

3.  Predicting G protein-coupled receptor downstream signaling by tissue expression.

Authors:  Yun Hao; Nicholas P Tatonetti
Journal:  Bioinformatics       Date:  2016-08-02       Impact factor: 6.937

4.  The repertoire of heterotrimeric G proteins and RGS proteins in Ciona intestinalis.

Authors:  R Prasobh; Narayanan Manoj
Journal:  PLoS One       Date:  2009-10-06       Impact factor: 3.240

Review 5.  Recent advances in computational studies of GPCR-G protein interactions.

Authors:  Jinan Wang; Yinglong Miao
Journal:  Adv Protein Chem Struct Biol       Date:  2019-01-03       Impact factor: 3.507

6.  GPCRs, G-proteins, effectors and their interactions: human-gpDB, a database employing visualization tools and data integration techniques.

Authors:  Venkata P Satagopam; Margarita C Theodoropoulou; Christos K Stampolakis; Georgios A Pavlopoulos; Nikolaos C Papandreou; Pantelis G Bagos; Reinhard Schneider; Stavros J Hamodrakas
Journal:  Database (Oxford)       Date:  2010-08-05       Impact factor: 3.451

7.  PKA regulatory subunits mediate synergy among conserved G-protein-coupled receptor cascades.

Authors:  Eduard Stefan; Mohan K Malleshaiah; Billy Breton; Po Hien Ear; Verena Bachmann; Michael Beyermann; Michel Bouvier; Stephen W Michnick
Journal:  Nat Commun       Date:  2011-12-20       Impact factor: 14.919

8.  Key challenges for the creation and maintenance of specialist protein resources.

Authors:  Gemma L Holliday; Amos Bairoch; Pantelis G Bagos; Arnaud Chatonnet; David J Craik; Robert D Finn; Bernard Henrissat; David Landsman; Gerard Manning; Nozomi Nagano; Claire O'Donovan; Kim D Pruitt; Neil D Rawlings; Milton Saier; Ramanathan Sowdhamini; Michael Spedding; Narayanaswamy Srinivasan; Gert Vriend; Patricia C Babbitt; Alex Bateman
Journal:  Proteins       Date:  2015-04-22

9.  HMPAS: Human Membrane Protein Analysis System.

Authors:  Min-Sung Kim; Gwan-Su Yi
Journal:  Proteome Sci       Date:  2013-11-07       Impact factor: 2.480

10.  IUPHAR-DB: the IUPHAR database of G protein-coupled receptors and ion channels.

Authors:  Anthony J Harmar; Rebecca A Hills; Edward M Rosser; Martin Jones; O Peter Buneman; Donald R Dunbar; Stuart D Greenhill; Valerie A Hale; Joanna L Sharman; Tom I Bonner; William A Catterall; Anthony P Davenport; Philippe Delagrange; Colin T Dollery; Steven M Foord; George A Gutman; Vincent Laudet; Richard R Neubig; Eliot H Ohlstein; Richard W Olsen; John Peters; Jean-Philippe Pin; Robert R Ruffolo; David B Searls; Mathew W Wright; Michael Spedding
Journal:  Nucleic Acids Res       Date:  2008-10-23       Impact factor: 16.971

  10 in total

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