OBJECTIVES: To observe the anti-tumor activities of honokiol on human ovarian tumor in vitro and in vivo. STUDY DESIGN: Cells were treated with honokiol, and the effects on proliferation and apoptosis were examined by MTT, DNA ladder, Hoechst staining, and flow cytometry assays. Expression of Bcl-2 members and caspase-3 were assessed. Measurements of tumor volume and microvessel densities (MVDs) were performed. RESULTS: Honokiol significantly inhibited proliferation and induced apoptosis, with alteration of Bcl-2 members and caspase-3. Administration of honokiol to tumor-bearing animals decreased MVD and resulted in inhibition of tumor growth. CONCLUSIONS: Honokiol could induce apoptosis and inhibit angiogenesis in vitro and in vivo, suggesting a novel and attractive therapeutic candidate for ovarian tumor treatment.
OBJECTIVES: To observe the anti-tumor activities of honokiol on humanovarian tumor in vitro and in vivo. STUDY DESIGN: Cells were treated with honokiol, and the effects on proliferation and apoptosis were examined by MTT, DNA ladder, Hoechst staining, and flow cytometry assays. Expression of Bcl-2 members and caspase-3 were assessed. Measurements of tumor volume and microvessel densities (MVDs) were performed. RESULTS:Honokiol significantly inhibited proliferation and induced apoptosis, with alteration of Bcl-2 members and caspase-3. Administration of honokiol to tumor-bearing animals decreased MVD and resulted in inhibition of tumor growth. CONCLUSIONS:Honokiol could induce apoptosis and inhibit angiogenesis in vitro and in vivo, suggesting a novel and attractive therapeutic candidate for ovarian tumor treatment.
Authors: Rebecca J Leeman-Neill; Quan Cai; Sonali C Joyce; Sufi M Thomas; Neil E Bhola; Daniel B Neill; Jack L Arbiser; Jennifer R Grandis Journal: Clin Cancer Res Date: 2010-04-13 Impact factor: 12.531
Authors: Gaurav Kaushik; Deep Kwatra; Dharmalingam Subramaniam; Roy A Jensen; Shrikant Anant; Joshua M V Mammen Journal: Am J Surg Date: 2014-10-02 Impact factor: 2.565