OBJECTIVES: Despite the well-defined genetics of FMF, limited information is available regarding the regulation of inflammation by cytokines. DESIGN AND METHODS: The levels of systemic cytokines and other markers of inflammation in FMF patients and control were measured by ELISA and Cytometric Bead Array (CBA). RESULTS: In FMF attack the levels of IL-6, IL-10, IL-17, TGF-beta, CRP, and sIL-2R were significantly different from the norm and FMF remission. CONCLUSIONS: Inflammation in FMF involves Treg and Th17 lineages.
OBJECTIVES: Despite the well-defined genetics of FMF, limited information is available regarding the regulation of inflammation by cytokines. DESIGN AND METHODS: The levels of systemic cytokines and other markers of inflammation in FMFpatients and control were measured by ELISA and Cytometric Bead Array (CBA). RESULTS: In FMF attack the levels of IL-6, IL-10, IL-17, TGF-beta, CRP, and sIL-2R were significantly different from the norm and FMF remission. CONCLUSIONS:Inflammation in FMF involves Treg and Th17 lineages.
Authors: D Rimar; I Rosner; G Slobodin; N Boulman; E Toubi; A Kessel; R Peri; M Rozenbaum Journal: Clin Rheumatol Date: 2012-01-11 Impact factor: 2.980
Authors: Zhanna A Ktsoyan; Natalia V Beloborodova; Anahit M Sedrakyan; George A Osipov; Zaruhi A Khachatryan; Denise Kelly; Gayane P Manukyan; Karine A Arakelova; Alvard I Hovhannisyan; Andrey Y Olenin; Arsen A Arakelyan; Karine A Ghazaryan; Rustam I Aminov Journal: Front Microbiol Date: 2011-01-20 Impact factor: 5.640
Authors: Zhanna A Ktsoyan; Natalia V Beloborodova; Anahit M Sedrakyan; George A Osipov; Zaruhi A Khachatryan; Gayane P Manukyan; Karine A Arakelova; Alvard I Hovhannisyan; Arsen A Arakelyan; Karine A Ghazaryan; Magdalina K Zakaryan; Rustam I Aminov Journal: Front Cell Infect Microbiol Date: 2013-01-28 Impact factor: 5.293
Authors: Zaruhi A Khachatryan; Zhanna A Ktsoyan; Gayane P Manukyan; Denise Kelly; Karine A Ghazaryan; Rustam I Aminov Journal: PLoS One Date: 2008-08-26 Impact factor: 3.240
Authors: Gayane P Manukyan; Karine A Ghazaryan; Zhanna A Ktsoyan; Zaruhi A Khachatryan; Karine A Arakelova; Denise Kelly; George Grant; Rustam I Aminov Journal: PLoS One Date: 2008-09-09 Impact factor: 3.240