| Literature DB >> 18439879 |
Joao Carlos M Marin1, Paula J Moura, Roberta M Cysneiros, Diego B Colugnati, Esper A Cavalheiro, Fulvio A Scorza, Gilberto F Xavier, Monica Zilbovicius, Marcos T Mercadante.
Abstract
Social behavior depends on the integrity of social brain circuitry. The temporal lobe is an important part of the social brain, and manifests morphological and functional alterations in autism spectrum disorders (ASD). Rats with temporal lobe epilepsy (TLE), induced with pilocarpine, were subjected to a social discrimination test that has been used to investigate potential animal models of ASD, and the results were compared with those for the control group. Rats with TLE exhibited fewer social behaviors than controls. No differences were observed in nonsocial behavior between groups. The results suggest an important role for the temporal lobe in regulating social behaviors. This animal model might be used to explore some questions about ASD pathophysiology.Entities:
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Year: 2008 PMID： 18439879 DOI： 10.1016/j.yebeh.2008.03.004
Source DB: PubMed Journal: Epilepsy Behav ISSN： 1525-5050 Impact factor: 2.937