N Hiraishi1, C K Y Yiu, N M King, F R Tay, D H Pashley. 1. Paediatric Dentistry and Orthodontics, Faculty of Dentistry, The University of Hong Kong, Prince Philip Dental Hospital, 34 Hospital Road, Pokfulam, Hong Kong SAR, China. hiraishinoriko@yahoo.com
Abstract
OBJECTIVES: The aim of this study was to evaluate chlorhexidine release from unfilled non-solvated methacrylate-based resins of increasing hydrophilicity and to examine relationships among Hoy's solubility parameters, water sorption, solubility and the rate of chlorhexidine release. METHODS: Resin discs were prepared from light-cured, experimental resin blends (R1, R2, R3, R4 and R5) containing 0.0, 0.2, 1.0 and 2.0 wt.% chlorhexidine diacetate (CDA). Discs were immersed in distilled water at 37 degrees C, and mass changes were recorded at different periods. Spectral measurements were made to follow change in optical densities of storage solution to examine chlorhexidine release kinetics. After a 28-day period, water sorption, solubility, and the cumulative chlorhexidine release were obtained. Additionally, antibacterial study was performed by observing the presence of inhibition zone against Streptococcus mutans. RESULTS: The most hydrophilic resin (R5) exhibited the highest chlorhexidine release rate. The most hydrophobic resin (R1) exhibited the lowest rate. However, no inhibition zone was produced by any specimens stored in water for 2 weeks. The addition of CDA increased solubility significantly but had no effect on water sorption. Significant positive correlations were seen between water sorption and the cumulative chlorhexidine release. SIGNIFICANCE: Chlorhexidine release from resins may be related to water-induced swelling, which in turn is enhanced by the hydrophilicity of cured polymer matrix.
OBJECTIVES: The aim of this study was to evaluate chlorhexidine release from unfilled non-solvated methacrylate-based resins of increasing hydrophilicity and to examine relationships among Hoy's solubility parameters, water sorption, solubility and the rate of chlorhexidine release. METHODS: Resin discs were prepared from light-cured, experimental resin blends (R1, R2, R3, R4 and R5) containing 0.0, 0.2, 1.0 and 2.0 wt.% chlorhexidine diacetate (CDA). Discs were immersed in distilled water at 37 degrees C, and mass changes were recorded at different periods. Spectral measurements were made to follow change in optical densities of storage solution to examine chlorhexidine release kinetics. After a 28-day period, water sorption, solubility, and the cumulative chlorhexidine release were obtained. Additionally, antibacterial study was performed by observing the presence of inhibition zone against Streptococcus mutans. RESULTS: The most hydrophilic resin (R5) exhibited the highest chlorhexidine release rate. The most hydrophobic resin (R1) exhibited the lowest rate. However, no inhibition zone was produced by any specimens stored in water for 2 weeks. The addition of CDA increased solubility significantly but had no effect on water sorption. Significant positive correlations were seen between water sorption and the cumulative chlorhexidine release. SIGNIFICANCE: Chlorhexidine release from resins may be related to water-induced swelling, which in turn is enhanced by the hydrophilicity of cured polymer matrix.
Authors: Bakul Wadgaonkar; Shuichi Ito; Nadia Svizero; David Elrod; Stephen Foulger; Robert Rodgers; Yoshiki Oshida; Kevin Kirkland; Jeremy Sword; Frederick Rueggeberg; Franklin Tay; David Pashley Journal: Biomaterials Date: 2006-02-28 Impact factor: 12.479
Authors: Danny Leung; David A Spratt; Jonathan Pratten; Kishor Gulabivala; Nicola J Mordan; Anne M Young Journal: Biomaterials Date: 2005-12 Impact factor: 12.479
Authors: Shuichi Ito; Masanori Hashimoto; Bakul Wadgaonkar; Nadia Svizero; Ricardo M Carvalho; Cynthia Yiu; Frederick A Rueggeberg; Stephen Foulger; Takashi Saito; Yoshihiro Nishitani; Masahiro Yoshiyama; Franklin R Tay; David H Pashley Journal: Biomaterials Date: 2005-11 Impact factor: 12.479
Authors: Cynthia K Y Yiu; Nigel M King; Marcela R O Carrilho; Salvatore Sauro; Frederick A Rueggeberg; Carlo Prati; Ricardo M Carvalho; David H Pashley; Franklin R Tay Journal: Biomaterials Date: 2005-10-13 Impact factor: 12.479
Authors: Leo Tjäderhane; Fabio D Nascimento; Lorenzo Breschi; Annalisa Mazzoni; Ivarne L S Tersariol; Saulo Geraldeli; Arzu Tezvergil-Mutluay; Marcela Carrilho; Ricardo M Carvalho; Franklin R Tay; David H Pashley Journal: Dent Mater Date: 2013-08-14 Impact factor: 5.304
Authors: Jongryul Kim; Toshikazu Uchiyama; Marcela Carrilho; Kelli A Agee; Annalisa Mazzoni; Lorenzo Breschi; Ricardo M Carvalho; Leo Tjäderhane; Stephen Looney; Courtney Wimmer; Arzu Tezvergil-Mutluay; Franklin R Tay; David H Pashley Journal: Dent Mater Date: 2010-05-15 Impact factor: 5.304
Authors: Marcela R Carrilho; Ricardo M Carvalho; Ethan N Sousa; José Nicolau; Lorenzo Breschi; Annalisa Mazzoni; Leo Tjäderhane; Franklin R Tay; Kelli Agee; David H Pashley Journal: Dent Mater Date: 2010-05-15 Impact factor: 5.304
Authors: Adriana Pigozzo Manso; Rosa Helena Miranda Grande; Ana Karina Bedran-Russo; Alessandra Reis; Alessandro D Loguercio; David Henry Pashley; Ricardo Marins Carvalho Journal: Dent Mater Date: 2014-05-09 Impact factor: 5.304
Authors: Heonjune Ryou; Gianluca Turco; Lorenzo Breschi; Franklin R Tay; David H Pashley; Dwayne Arola Journal: Dent Mater Date: 2015-12-30 Impact factor: 5.304