Literature DB >> 18439552

Polymorphisms of the HNF1A gene encoding hepatocyte nuclear factor-1 alpha are associated with C-reactive protein.

Alexander P Reiner1, Mathew J Barber, Yongtao Guan, Paul M Ridker, Leslie A Lange, Daniel I Chasman, Jeremy D Walston, Gregory M Cooper, Nancy S Jenny, Mark J Rieder, J Peter Durda, Joshua D Smith, John Novembre, Russell P Tracy, Jerome I Rotter, Matthew Stephens, Deborah A Nickerson, Ronald M Krauss.   

Abstract

Data from the Pharmacogenomics and Risk of Cardiovascular Disease (PARC) study and the Cardiovascular Health Study (CHS) provide independent and confirmatory evidence for association between common polymorphisms of the HNF1A gene encoding hepatocyte nuclear factor-1 alpha and plasma C-reactive protein (CRP) concentration. Analyses with the use of imputation-based methods to combine genotype data from both studies and to test untyped SNPs from the HapMap database identified several SNPs within a 5 kb region of HNF1A intron 1 with the strongest evidence of association with CRP phenotype.

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Year:  2008        PMID： 18439552      PMCID： PMC2427318          DOI： 10.1016/j.ajhg.2008.03.017

Source DB:  PubMed          Journal:  Am J Hum Genet        ISSN： 0002-9297            Impact factor:   11.025


  26 in total

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4.  Evaluation of nine automated high-sensitivity C-reactive protein methods: implications for clinical and epidemiological applications. Part 2.

Authors:  W L Roberts; L Moulton; T C Law; G Farrow; M Cooper-Anderson; J Savory; N Rifai
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6.  Loci related to metabolic-syndrome pathways including LEPR,HNF1A, IL6R, and GCKR associate with plasma C-reactive protein: the Women's Genome Health Study.

Authors:  Paul M Ridker; Guillaume Pare; Alex Parker; Robert Y L Zee; Jacqueline S Danik; Julie E Buring; David Kwiatkowski; Nancy R Cook; Joseph P Miletich; Daniel I Chasman
Journal:  Am J Hum Genet       Date:  2008-04-24       Impact factor: 11.025

7.  Heritability of C-reactive protein and association with apolipoprotein E genotypes in Japanese Americans.

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Review 8.  C-reactive protein gene polymorphisms, C-reactive protein blood levels, and cardiovascular disease risk.

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10.  Imputation-based analysis of association studies: candidate regions and quantitative traits.

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  94 in total

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6.  Metabolic and cardiovascular traits: an abundance of recently identified common genetic variants.

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Review 7.  Bringing genome-wide association findings into clinical use.

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Review 9.  Bayesian statistical methods for genetic association studies.

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Review 10.  Genetic mapping in human disease.

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