| Literature DB >> 18438405 |
Andre Franke1, Tobias Balschun, Tom H Karlsen, Jürgen Hedderich, Sandra May, Tim Lu, Dörthe Schuldt, Susanna Nikolaus, Philip Rosenstiel, Michael Krawczak, Stefan Schreiber.
Abstract
Following up on recent genome-wide association studies (GWAS) of Crohn's disease, we investigated 50 previously reported susceptibility loci in a German sample of individuals with Crohn's disease (n = 1,850) or ulcerative colitis (n = 1,103) and healthy controls (n = 1,817). Among these loci, we identified variants in 3p21.31, NKX2-3 and CCNY as susceptibility factors for both diseases, whereas variants in PTPN2, HERC2 and STAT3 were associated only with ulcerative colitis in our sample collection.Entities:
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Year: 2008 PMID： 18438405 DOI： 10.1038/ng.148
Source DB: PubMed Journal: Nat Genet ISSN： 1061-4036 Impact factor: 38.330