Literature DB >> 21968973

Genes differentially regulated by NKX2-3 in B cells between ulcerative colitis and Crohn's disease patients and possible involvement of EGR1.

Wei Yu1, Zhenwu Lin, John P Hegarty, Xi Chen, Ashley A Kelly, Yunhua Wang, Lisa S Poritz, Walter A Koltun.   

Abstract

Ulcerative colitis (UC) and Crohn's disease (CD) are two related yet different forms of chronic intestinal inflammation. We investigated the genes regulated by NKX2-3 in B cells from a UC patient by cDNA microarray and compared the results to those genes regulated by NKX2-3 in B cells from a CD patient. Genes regulated by NKX2-3 in B cells from UC were mainly involved in cell growth, inflammation, and immune response. Among the genes regulated by NKX2-3 in both UC and CD, expression of 145 genes was similarly altered and 34 genes was differentially affected by NKX2-3 knockdown. EGR1 was up-regulated in NKX2-3 knockdown B cells from UC while down-regulated in NKX2-3 knockdown B cells from CD. mRNA expressions of NKX2-3 and EGR1 were increased in diseased intestinal tissues from 19 CD patients. NKX2-3 may play different roles in UC and CD pathogenesis by differential regulation of EGR1.

Entities:  

Mesh：

Substances：

Year:  2012        PMID： 21968973     DOI： 10.1007/s10753-011-9390-9

Source DB:  PubMed          Journal:  Inflammation        ISSN： 0360-3997            Impact factor:   4.092


  39 in total

Review 1.  Nitric oxide in inflammatory bowel disease.

Authors:  Raymond K Cross; Keith T Wilson
Journal:  Inflamm Bowel Dis       Date:  2003-05       Impact factor: 5.325

2.  Egr-1, a master switch coordinating upregulation of divergent gene families underlying ischemic stress.

Authors:  S F Yan; T Fujita; J Lu; K Okada; Y Shan Zou; N Mackman; D J Pinsky; D M Stern
Journal:  Nat Med       Date:  2000-12       Impact factor: 53.440

3.  Nitric oxide regulates shear stress-induced early growth response-1. Expression via the extracellular signal-regulated kinase pathway in endothelial cells.

Authors:  J J Chiu; B S Wung; H J Hsieh; L W Lo; D L Wang
Journal:  Circ Res       Date:  1999-08-06       Impact factor: 17.367

Review 4.  Hypoxia/Hypoxemia-Induced activation of the procoagulant pathways and the pathogenesis of ischemia-associated thrombosis.

Authors:  S F Yan; N Mackman; W Kisiel; D M Stern; D J Pinsky
Journal:  Arterioscler Thromb Vasc Biol       Date:  1999-09       Impact factor: 8.311

5.  Expression of E-selectin, sialyl Lewis X, and macrophage inflammatory protein-1alpha by colonic epithelial cells in ulcerative colitis.

Authors:  B Vainer; O H Nielsen; T Horn
Journal:  Dig Dis Sci       Date:  1998-03       Impact factor: 3.199

6.  Genetic deficiency in the chemokine receptor CCR1 protects against acute Clostridium difficile toxin A enteritis in mice.

Authors:  Olivier Morteau; Ignazio Castagliuolo; Andreas Mykoniatis; Jeff Zacks; Michael Wlk; Bao Lu; Charalabos Pothoulakis; Norma P Gerard; Craig Gerard
Journal:  Gastroenterology       Date:  2002-03       Impact factor: 22.682

Review 7.  Early growth response protein 1 (Egr-1): prototype of a zinc-finger family of transcription factors.

Authors:  A Gashler; V P Sukhatme
Journal:  Prog Nucleic Acid Res Mol Biol       Date:  1995

8.  Proinflammatory role of leukocyte-derived Egr-1 in the development of murine postoperative ileus.

Authors:  Joachim Schmidt; Burkhard Stoffels; Beverley A Moore; R Savanh Chanthaphavong; Abigail R Mazie; Bettina M Buchholz; Anthony J Bauer
Journal:  Gastroenterology       Date:  2008-06-04       Impact factor: 22.682

9.  NKX2-3 transcriptional regulation of endothelin-1 and VEGF signaling in human intestinal microvascular endothelial cells.

Authors:  Wei Yu; John P Hegarty; Arthur Berg; Xi Chen; Gail West; Ashley A Kelly; Yunhua Wang; Lisa S Poritz; Walter A Koltun; Zhenwu Lin
Journal:  PLoS One       Date:  2011-05-26       Impact factor: 3.240

10.  Dissection of the inflammatory bowel disease transcriptome using genome-wide cDNA microarrays.

Authors:  Christine M Costello; Nancy Mah; Robert Häsler; Philip Rosenstiel; Georg H Waetzig; Andreas Hahn; Tim Lu; Yesim Gurbuz; Susanna Nikolaus; Mario Albrecht; Jochen Hampe; Ralph Lucius; Günther Klöppel; Holger Eickhoff; Hans Lehrach; Thomas Lengauer; Stefan Schreiber
Journal:  PLoS Med       Date:  2005-08-23       Impact factor: 11.069
View more
  4 in total

Review 1.  Intestinal antigen-presenting cells in mucosal immune homeostasis: crosstalk between dendritic cells, macrophages and B-cells.

Authors:  Elizabeth R Mann; Xuhang Li
Journal:  World J Gastroenterol       Date:  2014-08-07       Impact factor: 5.742

2.  Peripheral blood methylation profiling of female Crohn's disease patients.

Authors:  Andrew Y F Li Yim; Nicolette W Duijvis; Jing Zhao; Wouter J de Jonge; Geert R A M D'Haens; Marcel M A M Mannens; Adri N P M Mul; Anje A Te Velde; Peter Henneman
Journal:  Clin Epigenetics       Date:  2016-06-08       Impact factor: 6.551

3.  A distinct epigenetic profile distinguishes stenotic from non-inflamed fibroblasts in the ileal mucosa of Crohn's disease patients.

Authors:  Andrew Y F Li Yim; Jessica R de Bruyn; Nicolette W Duijvis; Catriona Sharp; Enrico Ferrero; Wouter J de Jonge; Manon E Wildenberg; Marcel M A M Mannens; Christianne J Buskens; Geert R D'Haens; Peter Henneman; Anje A Te Velde
Journal:  PLoS One       Date:  2018-12-27       Impact factor: 3.240

4.  Identification and validation of the common pathogenesis and hub biomarkers in Hirschsprung disease complicated with Crohn's disease.

Authors:  Jing Wang; Zejian Li; Jun Xiao; Luyao Wu; Ke Chen; Tianqi Zhu; Chenzhao Feng; Didi Zhuansun; Xinyao Meng; Jiexiong Feng
Journal:  Front Immunol       Date:  2022-09-28       Impact factor: 8.786
  4 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.