Literature DB >> 18437412

Comments on "Radiofrequency electromagnetic fields (UMTS, 1,950 MHz) induce genotoxic effects in vitro in human fibroblasts but not in lymphocytes" by Schwarz et al. (Int Arch Occup Environ Health 2008: doi: 10.1007/s00420-008-0305-5).

Alexander Lerchl1.   

Abstract

BACKGROUND: A recent publication by Schwarz et al. describes the effects of exposure of human fibroblast and lymphocytes to radiofrequency-electromagnetic fields at frequencies used for communication with mobile phones. Even at very low specific absorption rates of 0.05 W/kg, thus well below internationally accepted exposure limits, significant effects were seen in fibroblasts whose DNA molecules were damaged as assessed by their comet tail factor (CTF) in the comet assay. AREAS OF CONCERN: The CTF mean values and the standard deviations of the replicates revealed very low coefficients of variation, ranging from 1.2 to 4.9% (average 2.9%), which are in contrast to much higher variations reported by others. Moreover, inter-individual differences of the CTF values strongly disagree with the previously published data from the same group of researchers.
CONCLUSION: The critical analysis of the data given in the figures and the tables furthermore reveal peculiar miscalculations and statistical oddities which give rise to concern about the origin of the reported data.

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Year:  2008        PMID: 18437412     DOI: 10.1007/s00420-008-0323-3

Source DB:  PubMed          Journal:  Int Arch Occup Environ Health        ISSN: 0340-0131            Impact factor:   3.015


  13 in total

1.  Non-thermal DNA breakage by mobile-phone radiation (1800 MHz) in human fibroblasts and in transformed GFSH-R17 rat granulosa cells in vitro.

Authors:  Elisabeth Diem; Claudia Schwarz; Franz Adlkofer; Oswald Jahn; Hugo Rüdiger
Journal:  Mutat Res       Date:  2005-06-06       Impact factor: 2.433

2.  Comments on: "DNA strand breaks" by Diem et al. [Mutat. Res. 583 (2005) 178-183] and Ivancsits et al. [Mutat. Res. 583 (2005) 184-188].

Authors:  James P McNamee; Maria Rosaria Scarfi
Journal:  Mutat Res       Date:  2005-12-27       Impact factor: 2.433

3.  Carcinogenicity study of GSM and DCS wireless communication signals in B6C3F1 mice.

Authors:  Thomas Tillmann; Heinrich Ernst; Sven Ebert; Niels Kuster; Wolfgang Behnke; Susanne Rittinghausen; Clemens Dasenbrock
Journal:  Bioelectromagnetics       Date:  2007-04       Impact factor: 2.010

4.  Lymphomas in E mu-Pim1 transgenic mice exposed to pulsed 900 MHZ electromagnetic fields.

Authors:  M H Repacholi; A Basten; V Gebski; D Noonan; J Finnie; A W Harris
Journal:  Radiat Res       Date:  1997-05       Impact factor: 2.841

5.  Genotoxic effects of exposure to radiofrequency electromagnetic fields (RF-EMF) in cultured mammalian cells are not independently reproducible.

Authors:  Günter Speit; Petra Schütz; Heike Hoffmann
Journal:  Mutat Res       Date:  2006-09-25       Impact factor: 2.433

6.  Basal levels of DNA strand breaks in human leukocytes determined by comet assay.

Authors:  Elisabeth Diem; Sabine Ivancsits; Hugo W Rüdiger
Journal:  J Toxicol Environ Health A       Date:  2002-05-10

Review 7.  Controversial cytogenetic observations in mammalian somatic cells exposed to radiofrequency radiation.

Authors:  Guenter Obe
Journal:  Radiat Res       Date:  2004-11       Impact factor: 2.841

Review 8.  Guidelines for limiting exposure to time-varying electric, magnetic, and electromagnetic fields (up to 300 GHz). International Commission on Non-Ionizing Radiation Protection.

Authors: 
Journal:  Health Phys       Date:  1998-04       Impact factor: 1.316

9.  Long-term exposure of E-mu-Pim1 transgenic mice to 898.4 MHz microwaves does not increase lymphoma incidence.

Authors:  Tammy D Utteridge; Val Gebski; John W Finnie; Barrie Vernon-Roberts; Tim R Kuchel
Journal:  Radiat Res       Date:  2002-09       Impact factor: 2.841

10.  Radiofrequency electromagnetic fields (UMTS, 1,950 MHz) induce genotoxic effects in vitro in human fibroblasts but not in lymphocytes.

Authors:  Claudia Schwarz; Elisabeth Kratochvil; Alexander Pilger; Niels Kuster; Franz Adlkofer; Hugo W Rüdiger
Journal:  Int Arch Occup Environ Health       Date:  2008-02-16       Impact factor: 3.015

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  2 in total

1.  Editorial expression of concern regarding: Pilger A et al. (2004) No effects of intermittent 50 Hz EMF on cytoplasmic free calcium and on the mitochondrial membrane potential in human diploid fibroblasts, Radiat Environ Biophys 43:203-207.

Authors:  Anna A Friedl; Werner Rühm
Journal:  Radiat Environ Biophys       Date:  2010-04-08       Impact factor: 1.925

2.  Expression of concern.

Authors:  H Drexler; K H Schaller
Journal:  Int Arch Occup Environ Health       Date:  2008-10-11       Impact factor: 3.015

  2 in total

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