Meta-analysis of four randomized controlled trials on long-term outcomes of coronary artery bypass grafting versus percutaneous coronary intervention with stenting for multivessel coronary artery disease.

To provide a quantitative analysis of long-term clinical outcomes, a meta-analysis of 4 randomized controlled trials of percutaneous coronary intervention (PCI) with stenting versus coronary artery bypass grafting (CABG) for multivessel coronary artery disease was conducted. The search identified 4 randomized controlled trials of PCI with stenting versus CABG that enrolled patients with multivessel coronary artery disease. In conclusion, pooled analysis demonstrated no statistically significant differences in death, cardiac death, Q-wave myocardial infarction, cerebrovascular accidents, and angina pectoris between PCI with stenting and CABG. However, PCI with stenting was associated with a statistically significant increase in subsequent PCI, subsequent CABG, subsequent revascularization (PCI or CABG), and major adverse cardiovascular events relative to CABG.