Literature DB >> 18435920

Differential hTERT mRNA processing between young and older glioma patients.

A Shervington1, R Patel.   

Abstract

The amplification of hTERT was detected in glioma tissues, although telomerase activity was not always found within these specimens. The aim of this study was to correlate the level of hTERT transcription with telomerase activity in two glioma age groups. hTERT was significantly transcribed at similar copy numbers in both age groups. However, these mRNAs translated to telomerase in 100% of the young compared to only 25% of the older patients. While hTERT transcription correlated directly to telomerase protein level and activity, as well as longer telomeres in the young group, such correlations were missing in the older group.

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Year:  2008        PMID： 18435920     DOI： 10.1016/j.febslet.2008.04.027

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  8 in total

1.  Evaluating the potential of circulating hTERT levels in glioma: can plasma levels serve as an independent prognostic marker?

Authors:  Puneet Gandhi; Richa Khare; Nitin Garg
Journal:  J Neurooncol       Date:  2017-07-29       Impact factor: 4.130

2.  Prognostic quality of activating TERT promoter mutations in glioblastoma: interaction with the rs2853669 polymorphism and patient age at diagnosis.

Authors:  Sabine Spiegl-Kreinecker; Daniela Lötsch; Bahil Ghanim; Christine Pirker; Thomas Mohr; Magdalena Laaber; Serge Weis; Alfred Olschowski; Gerald Webersinke; Josef Pichler; Walter Berger
Journal:  Neuro Oncol       Date:  2015-02-13       Impact factor: 12.300

3.  Changes in telomerase activity due to alternative splicing of human telomerase reverse transcriptase in colorectal cancer.

Authors:  Hei Cheul Jeung; Sun Young Rha; Sang Joon Shin; Joong Bae Ahn; Kyu Hyun Park; Tae Soo Kim; Jin Ju Kim; Jae Kyung Roh; Hyun Cheol Chung
Journal:  Oncol Lett       Date:  2017-06-21       Impact factor: 2.967

4.  Prognostic significance of telomerase-associated parameters in glioblastoma: effect of patient age.

Authors:  Daniela Lötsch; Bahil Ghanim; Magdalena Laaber; Gabriele Wurm; Serge Weis; Stefan Lenz; Gerald Webersinke; Josef Pichler; Walter Berger; Sabine Spiegl-Kreinecker
Journal:  Neuro Oncol       Date:  2013-02-07       Impact factor: 12.300

5.  Telomerase downregulation in cancer brain stem cell.

Authors:  Amal Shervington; Chen Lu; Rahima Patel; Leroy Shervington
Journal:  Mol Cell Biochem       Date:  2009-05-09       Impact factor: 3.396

6.  Assessment Effects of Resveratrol on Human Telomerase Reverse Transcriptase Messenger Ribonucleic Acid Transcript in Human Glioblastoma.

Authors:  Azin Mirzazadeh; Majid Kheirollahi; Ehsan Farashahi; Fatemeh Sadeghian-Nodoushan; Mohammad Hasan Sheikhha; Behrouz Aflatoonian
Journal:  Adv Biomed Res       Date:  2017-06-27

7.  Unique case of oligoastrocytoma with recurrence and grade progression: Exhibiting differential expression of high mobility group-A1 and human telomerase reverse transcriptase.

Authors:  Puneet Gandhi; Richa Khare; Kavita Niraj; Nitin Garg; Sandeep K Sorte; Hanni Gulwani
Journal:  World J Clin Cases       Date:  2016-09-16       Impact factor: 1.337

8.  Alternative splicing of human telomerase reverse transcriptase in gliomas and its modulation mediated by CX-5461.

Authors:  Guihong Li; Jing Shen; Junguo Cao; Guangtong Zhou; Ting Lei; Yuxue Sun; Haijun Gao; Yaonan Ding; Weidong Xu; Zhixin Zhan; Yong Chen; Haiyan Huang
Journal:  J Exp Clin Cancer Res       Date:  2018-04-10
  8 in total

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