Literature DB >> 18434148

Synthesis and PKCtheta inhibitory activity of a series of 4-(indol-5-ylamino)thieno[2,3-b]pyridine-5-carbonitriles.

Diane H Boschelli1, Biqi Wu, Ana Carolina Barrios Sosa, Joan Chen, Magda Asselin, Derek C Cole, Julie Lee, Xiaoke Yang, Divya Chaudhary.   

Abstract

The thieno[2,3-b]pyridine-5-carbonitrile with a 5-indolylamine at C-4 and a phenyl group at C-2 had a moderate activity against PKCtheta. Optimization of the groups at C-4 and C-2 led to analog 29, which has an IC(50) value of 7.5nM for the inhibition of PKCtheta.

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Year:  2008        PMID： 18434148     DOI： 10.1016/j.bmcl.2008.03.077

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  3 in total

Review 1.  The Novel PKCθ from Benchtop to Clinic.

Authors:  Rouba Hage-Sleiman; Asmaa B Hamze; Lina Reslan; Hadile Kobeissy; Ghassan Dbaibo
Journal:  J Immunol Res       Date:  2015-05-19       Impact factor: 4.818

2.  Speculative assessment, molecular composition, PDOS, topology exploration (ELF, LOL, RDG), ligand-protein interactions, on 5-bromo-3-nitropyridine-2-carbonitrile.

Authors:  K Arulaabaranam; S Muthu; G Mani; A S Ben Geoffrey
Journal:  Heliyon       Date:  2021-05-21

3.  3,4,6-Tri-amino-N-phenyl-thieno[2,3-b]pyridine-2-carboxamide.

Authors:  Shaaban K Mohamed; Joel T Mague; Mehmet Akkurt; Bahgat R M Hussein; Mustafa R Albayati
Journal:  Acta Crystallogr Sect E Struct Rep Online       Date:  2014-06-25
  3 in total

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