Literature DB >> 18434144

Identification of long chain alkylidenemalonates as novel small molecule modulators of histone acetyltransferases.

Gianluca Sbardella1, Sabrina Castellano, Caterina Vicidomini, Dante Rotili, Angela Nebbioso, Marco Miceli, Lucia Altucci, Antonello Mai.   

Abstract

Pentadecylidenemalonate 1b, a simplified analogue of anacardic acid, was identified as the first mixed activator/inhibitor of histone acetyltransferases (HATs). It potentiates PCAF HAT activity while inhibiting those of p300/CBP and recombinant CBP. The remarkable apoptotic effect together with the ability to selectively acetylate histone versus non-histone substrates appoint 1b as a lead for the development of anticancer drugs.

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Year:  2008        PMID： 18434144     DOI： 10.1016/j.bmcl.2008.04.017

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  21 in total

Review 1.  Chemical biology of histone acetyltransferase natural compounds modulators.

Authors:  Fabrizio Dal Piaz; Antonio Vassallo; Osmany Cuesta Rubio; Sabrina Castellano; Gianluca Sbardella; Nunziatina De Tommasi
Journal:  Mol Divers       Date:  2011-01-01       Impact factor: 2.943

2.  Small molecule inhibitors of histone acetyltransferase Tip60.

Authors:  Jiang Wu; Juxian Wang; Minyong Li; Yutao Yang; Binghe Wang; Y George Zheng
Journal:  Bioorg Chem       Date:  2010-12-07       Impact factor: 5.275

3.  Nε-lysine acetylation determines dissociation from GAP junctions and lateralization of connexin 43 in normal and dystrophic heart.

Authors:  Claudia Colussi; Jessica Rosati; Stefania Straino; Francesco Spallotta; Roberta Berni; Donatella Stilli; Stefano Rossi; Ezio Musso; Emilio Macchi; Antonello Mai; Gianluca Sbardella; Sabrina Castellano; Cristina Chimenti; Andrea Frustaci; Angela Nebbioso; Lucia Altucci; Maurizio C Capogrossi; Carlo Gaetano
Journal:  Proc Natl Acad Sci U S A       Date:  2011-01-31       Impact factor: 11.205

Review 4.  Acetyltransferases (HATs) as targets for neurological therapeutics.

Authors:  Anne Schneider; Snehajyoti Chatterjee; Olivier Bousiges; B Ruthrotha Selvi; Amrutha Swaminathan; Raphaelle Cassel; Frédéric Blanc; Tapas K Kundu; Anne-Laurence Boutillier
Journal:  Neurotherapeutics       Date:  2013-10       Impact factor: 7.620

Review 5.  Biological activity of phenolic lipids.

Authors:  Maria Stasiuk; A Kozubek
Journal:  Cell Mol Life Sci       Date:  2010-03       Impact factor: 9.261

6.  p300/CBP-associated factor selectively regulates the extinction of conditioned fear.

Authors:  Wei Wei; Carlos M Coelho; Xiang Li; Roger Marek; Shanzhi Yan; Shawn Anderson; David Meyers; Chandrani Mukherjee; Gianluca Sbardella; Sabrina Castellano; Ciro Milite; Dante Rotili; Antonello Mai; Philip A Cole; Pankaj Sah; Michael S Kobor; Timothy W Bredy
Journal:  J Neurosci       Date:  2012-08-29       Impact factor: 6.167

Review 7.  Cancer chemoprevention by dietary polyphenols: promising role for epigenetics.

Authors:  Alexander Link; Francesc Balaguer; Ajay Goel
Journal:  Biochem Pharmacol       Date:  2010-06-26       Impact factor: 5.858

8.  Glucagon regulates gluconeogenesis through KAT2B- and WDR5-mediated epigenetic effects.

Authors:  Kim Ravnskjaer; Meghan F Hogan; Denise Lackey; Laszlo Tora; Sharon Y R Dent; Jerrold Olefsky; Marc Montminy
Journal:  J Clin Invest       Date:  2013-09-24       Impact factor: 14.808

Review 9.  Regulation of epigenetic state by non-histone chromatin proteins and transcription factors: Implications in disease.

Authors:  Sweta Sikder; Stephanie Kaypee; Tapas K Kundu
Journal:  J Biosci       Date:  2020       Impact factor: 1.826

10.  6-alkylsalicylates are selective Tip60 inhibitors and target the acetyl-CoA binding site.

Authors:  Massimo Ghizzoni; Jiang Wu; Tielong Gao; Hidde J Haisma; Frank J Dekker; Y George Zheng
Journal:  Eur J Med Chem       Date:  2011-11-10       Impact factor: 6.514
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